| hrHPV阳性TCT阴性的妇女2年后随访研究 |
| 投稿时间：2015-09-30 修订日期：2015-10-10 点此下载全文 |
| 引用本文：徐彩炎,张为远,张淞文,武明辉.hrHPV阳性TCT阴性的妇女2年后随访研究[J].医学研究杂志,2015,44(12):70-74 |
| DOI：
10.11969/j.issn.1673-548X.2015.12.019 |
| 摘要点击次数: 754 |
| 全文下载次数: 860 |
|
| 基金项目:北京市科委重大科研项目(D0906008040491) |
|
| 中文摘要:目的评估北京社区中高危型人乳头瘤病毒(hight risk human papillomavirus,hrHPV)阳性、宫颈细胞学(thinprep cytology test,TCT)阴性的已婚女性患者2年后hrHPV感染的转归及引起宫颈病变的发生、发展情况。方法对筛查为hrHPV(+)/TCT(-)的女性患者2年后进行随访,重复行妇科检查、细胞学检查、宫颈组织病理学检查及hrHPV检测。计算HPV清除率、持续感染率,分析影响因素,评估2年后宫颈病变发生、发展情况。结果hrRHPV(+)/TCT(-)的妇女2年后随访,62.5% hr HPV被清除,37.5%持续感染;68.2%宫颈组织学正常,24.0%发生宫颈上皮内瘤样病变Ⅰ级(cervical intraepithelial neoplasia,CINⅠ),7.8%发生CIN Ⅱ及以上宫颈病变。CIN Ⅱ及以上宫颈病变者100%存在hrHPV持续感染。合并细菌感染的女性与无细菌感染者相比2年后HPV转归(χ2=2.84,P=0.092)及宫颈病变发生率差异无统计学意义(χ2=0.93,P=0.628)。结论HPV的持续感染是宫颈病变发生的重要因素,无论TCT结果如何,hrHPV都可能引起宫颈病变的发生发展。检测短期内hrHPV感染的持续性对于临床评价hrHPV感染引起的CINⅡ~Ⅲ风险是很有意义的。 |
| 中文关键词:人乳头瘤状病毒 宫颈病变 随访研究 |
| |
| Risk of Subsequent High-grade Cervical Lesions in High-risk HPV-positive and Normal Smear Women in Two Years. |
|
|
| Abstract:Objective To know more information about the risk of subsequent high-grade cervical lesions in hrHPV positive and normal smear women in two years. Methods We examined 104 women with positive hrHPV and normal cytology,who were followed for development of cervical neoplasia.We estimated the proportion of women developing cervical lesions of different types after two years and the consistent HPV infection rate. Results Among the women with normal TCT and positive hybrid capture 2 test(HC2), 25% had a subsequent abnormal TCT within 2 years, of them 3.8% were CINⅡ-Ⅲ. The pathological result show cervical cancer case. Among these women, 37.5% had a consistent HPV infection. Conclusion Even a single positive HPV test in cytologically negative women is substantially predictive of CINⅡ-Ⅲ, suggesting that HC2 testing can help stratify women into different risk categories. |
| keywords:Human papillomavirus Cervical lesion Follow-up studies |
| 查看全文 查看/发表评论 下载PDF阅读器 |
|
|
|
