慢性阻塞性肺疾病患者血清25-羟维生素D水平与Th17相关细胞因子表达的关系
投稿时间:2015-04-03  修订日期:2015-05-04  点此下载全文
引用本文:蒋加雁,李雨,郑闯.慢性阻塞性肺疾病患者血清25-羟维生素D水平与Th17相关细胞因子表达的关系[J].医学研究杂志,2015,44(12):121-124
DOI: 10.11969/j.issn.1673-548X.2015.12.033
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作者单位E-mail
蒋加雁 325405 温州医科大学附属第二医院平阳院区呼吸内科 jjy203203@sina.com 
李雨 325405 温州医科大学附属第二医院平阳院区呼吸内科  
郑闯 325405 温州医科大学附属第二医院平阳院区呼吸内科  
中文摘要:目的探讨慢性阻塞性肺疾病(COPD)患者血清25-羟维生素D[25(OH)D]水平与Th17相关细胞因子表达水平的关系。方法收集124例COPD患者和188名对照者,采用酶联免疫吸附法检测血清25(OH)D、IL-17A、IL-6、IL-21和IL-23水平。结果与对照组相比,COPD患者中血清25(OH)D平均水平显著降低(P=0.007),而血清IL-17A、IL-6、IL-21和IL-23平均水平显著增高(P=0.002、0.005、0.001、0.005)。与稳定期COPD患者相比,急性加重期患者中血清25(OH)D平均水平显著降低(P=0.000),而血清IL-17A、IL-6、IL-21和IL-23平均水平显著增高(P=0.002、0.000、0.001、0.007)。与从未吸烟或已戒烟的COPD患者相比,吸烟患者中血清25(OH)D平均水平显著降低(P=0.000),而血清IL-17A、IL-6、IL-21和IL-23平均水平显著增高(P=0.007、0.003、0.006、0.006)。此外,与未经吸入性糖皮质激素(ICS)治疗的COPD患者相比,经ICS治疗的患者中血清IL-17A、IL-6、IL-21和IL-23的平均水平均显著降低(P=0.004、0.004、0.040、0.010)。线性回归分析显示,COPD患者中血清25(OH)D平均水平与IL-17A (β=-0.164, P=0.002)、IL-23(β=-0.138, P=0.006)、IL-6(β=-0.720, P=0.000)呈负相关。结论COPD患者中血清25(OH)D水平与Th17相关细胞因子表达水平密切相关,并且都能影响患者的临床病理特征。
中文关键词:慢性阻塞性肺疾病  维生素D  Th17细胞
 
Study on the Relationship between Serum 25-Hydroxyvitamin D Levels and Th17 Related Cytokines Expressions in Patients with Chronic Obstructive Pulmonary Disease.
Abstract:Objective Our study aimed to analyze the relationship between serum 25-hydroxyvitamin D[25(OH)D] levels and Th17 related cytokines expressions in patients with chronic obstructive pulmonary disease (COPD). Methods A total of 124 COPD patients and 188 controls were collected. Serum levels of 25(OH)D, IL-17A, IL-6, IL-21 and IL-23 were examined by enzyme-linked immunosorbent assay. Results Compared to the controls, average 25(OH)D level in COPD patients was decreased (P=0.007), whereas the levels of IL-17A, IL-6, IL-21 and IL-23 were increased (P=0.002, 0.005, 0.001, 0.005). The similar conclusions were drawn from the levels of 25(OH)D, IL-17A, IL-6, IL-21 and IL-23 in patients with acute exacerbations of COPD compared to those on stable phase (P=0.000, 0.002, 0.000, 0.001, 0.007). In comparision to those with never smoking or ex-smoking, moreover, average 25(OH)D level in patients with current smoking was decreased (P=0.000), whereas the levels of IL-17A, IL-6, IL-21 and IL-23 were increased (P=0.007, 0.003, 0.006, 0.006). Additionally, the levels of IL-17A, IL-6, IL-21 and IL-23 were lower in COPD patients with inhaled corticosteroid (ICS) treatment than in those without ICS treatment (P=0.004, 0.004, 0.04, 0.01). By means of linear regression analysis, furthermore, average 25(OH)D level in COPD patients was shown to be reversely linked to the levels of IL-17A (β=-0.164, P=0.002), IL-23(β=-0.138, P=0.006) and IL-6(β=-0.720, P<0.001), respectively. Conclusion Serum 25(OH)D levels were closely related to Th17 related cytokines expressions in COPD patients. Moreover, both of them impacted the clinical features of COPD patients.
keywords:Chronic obstructive pulmonary disease  Vitamin D  Th17 cell
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