| 预防性应用他汀类药物对单纯冠脉旁路移植术后早期并发症的影响 |
| 投稿时间：2015-06-11 修订日期：2015-06-19 点此下载全文 |
| 引用本文：周煜东,高长青,肖苍松,王嵘,吴扬,龚志云.预防性应用他汀类药物对单纯冠脉旁路移植术后早期并发症的影响[J].医学研究杂志,2016,45(1):54-57,78 |
| DOI：
10.11969/j.issn.1673-548X.2016.01.014 |
| 摘要点击次数: 1185 |
| 全文下载次数: 1032 |
|
| 基金项目:国家自然科学基金资助项目(面上项目)(30971182) |
|
| 中文摘要:目的 研究术前预防性应用他汀类药物是否可以降低冠脉旁路移植术后早期兵并发症。方法 回顾性分析2013年6月~2014年8月中国人民解放军总医院心血管外科接受单纯体外循环下冠状动脉旁路移植术(CCABG)患者共199例;根据术前是否应用他汀类降脂药物将病例分为他汀类药物组99例(男性84例,女性15例)(至少术前7天开始服用他汀类药物:瑞舒伐他汀钙片10毫克/晚或阿托伐他汀钙片20毫克/晚);对照组100例(男性88例,女性12例)。观察术后30天内出现主要心脏相关不良事件(主要包括死亡、伴或不伴有病理性Q波的围术期心肌梗死、再次再血管化等)。结果 他汀类药物组术后早期发生并发症概率与对照组比较,差异无统计学意义(P>0.05),两组均无围术期死亡及再次再血管化病例。两组术前及术后3天内肌钙蛋白T、CK-MB和C反应蛋白水平比较,差异无统计学意义(P>0.05);术前及术后3天内肌钙蛋白T、CK-MB升高超过参考值5倍以上病例差异无统计学意义(P>0.05)。他汀类药物组中,术后肌钙蛋白T升高超过参考值5倍的患者占25.3%,对照组则有26%;他汀类药物组中,术后CK-MB升高超过参考值5倍的患者占10.1%,对照组则有7%,差异均无统计学意义(P>0.05)。结论 根据本研究结果,预防性应用他汀类药物能否降低冠脉旁路移植术后早期心肌损伤及炎性反应,进而减少术后早期并发症尚不确定。 |
| 中文关键词:他汀类药物 冠状动脉分流术 术后并发症 |
| |
| Impact of Preoperative Statin Therapy on Early Postoperative Complication of Coronary Artery Bypass Grafting |
|
|
| Abstract:Objective To investigate whether preoperative statin administration affects incidence of incidence of early postoperative complication of coronary artery bypass grafting. Methods A total of 199 cases who received coronary artery bypass grafting alone from June, 2013 to August 2014 were included in. Data were prospectively collected and retrospectively studied. Subjects were divided into 2 groups according to with or without preoperative statin administration. There were 99 cases in Statin group (84 males) while 100 cases in Non-statin group (88 males). Statin administration began in at least 7 days before operation. All cases were followed till 30 days postoperatively for major adverse cardiovascular events including death, newly occurred postoperative myocardial infarction with or without pathological Q waves and redo revascularization. Results The occurrence of early postoperative complications in statin group was not significantly different with non-statin group, and no perioperative deaths and redo revascularization cases occured in both group. Levels of creatine kinase myocardial isozyme (CK-MB), cardiac troponin T (TnT) and C-reactive protein(CPR) had no statistical difference preoperatively and postoperatively within 3 days after CABG. There was no significant statistical differences of CK-MB and TnT above the upper normal limit More than 5 times(>5×ULN) after operation.CK-MB and TnT>5×ULN had no significant statistical differences after surgery. Conclusion In this study, there is no significant effect of preoperative statin dministration on myocardial injury and inflammatory response,which culd thus reduce early complication of coronary artery bypass grafting. |
| keywords:Cystatins Coronary artery bypass Postoperative complication |
| 查看全文 查看/发表评论 下载PDF阅读器 |
|
|
|
