| Ⅳ期非小细胞肺癌预后因素分析 |
| 投稿时间：2015-09-03 修订日期：2015-09-12 点此下载全文 |
| 引用本文：杨开来,李简.Ⅳ期非小细胞肺癌预后因素分析[J].医学研究杂志,2016,45(1):74-78 |
| DOI：
10.11969/j.issn.1673-548X.2016.01.019 |
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| 中文摘要:目的 探寻Ⅳ期非小细胞肺癌(non-small cell lung cancer,NSCLC)患者的预后因素。方法 回顾性分析2012年11月1日~2013年12月31日北京大学第一医院胸外科所收住的初诊Ⅳ期非小细胞肺癌患者共88例,收集资料完成随访,采用Kaplan-Meier法进行生存分析,采用Log-rank检验比较生存期的差异,用COX比例风险模型进行预后影响因素分析。结果 患者整体中位生存时间为27个月,1年生存率为73.4%。单因素分析显示,N分期(P=0.039)、是否手术(P=0.004)、体重减轻(P=0.004)、白蛋白水平(P=0.036)是影响预后的因素;多因素分析显示,年龄(P=0.045)、T分期(P=0.049)、是否手术(P=0.003)、体重减轻(P=0.001)是影响预后的因素。结论 是否采用手术治疗、是否体重减轻是影响Ⅳ期非小细胞肺癌患者的重要预后因素。采取包含手术在内的综合治疗者预后较好,体重下降者预后较差。筛选合适的Ⅳ期NSCLC患者并行手术治疗可能为Ⅳ期NSCLC治疗方式的选择之一。 |
| 中文关键词:非小细胞肺癌 Ⅳ期 预后因素 |
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| Analysis of Prognostic Factors for Stage Ⅳ Non-small Cell Lung Cancer |
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| Abstract:Objective To analyze the prognostic factors for stage Ⅳ non-small cell lung cancer. Methods Retrospective study was performed for clinical record of 88 patients with stage Ⅳ non-small cell lung cancer from Nov 2012 to Dec 2013 in thoracic surgery department of Peking University First Hospital. Survival analysis was evaluated through Kaplan-Meier and Log-rank tests,and multivariate analysis was performed using COX proportional hazards regression model. Results The median survival time was 27 months,and 1 year survival rate was 73.4%. The univariate analysis suggested that N staging (P=0.039), operation (P=0.004), weight loss (P=0.004), albumin (P=0.036) significantly influenced survival of stage Ⅳ NSCLC. Multivariate analysis suggested that age (P=0.045), T staging (P=0.049), and operation (P=0.003), weight loss (P=0.001) were the independent factors of survival. Conclusion Operation,weight loss are the prognostic factors of patients with stage Ⅳ non-small cell lung cancer.Patients be treated with surgery included have better prognosis; weight loss indicate worse prognosis. Surgery under suitable screening of patients with stage Ⅳ NSCLC may be one of the parallel treatment options. |
| keywords:Non-small cell lung cancer stage Ⅳ Prognosis factors |
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