| 不同半夏炮制品对小鼠镇静作用的比较 |
| 投稿时间：2015-06-25 修订日期：2015-07-09 点此下载全文 |
| 引用本文：方媚媚,林思思,袁拯忠.不同半夏炮制品对小鼠镇静作用的比较[J].医学研究杂志,2016,45(2):71-75 |
| DOI：
10.11969/j.issn.1673-548X.2016.02.019 |
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| 基金项目:浙江省中医药优秀青年人才基金资助项目(2011ZQ014) |
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| 中文摘要:目的 比较不同浓度的生半夏、清半夏、法半夏、姜半夏对小鼠的镇静作用。方法 分别将清、法、姜半夏配置成低、中、高剂量组,浓度0.45、0.9、1.80g/ml。生半夏配置低、中、高剂量组,浓度0.2、0.4、0.8g/ml。以地西泮为阳性对照组(0.1mg/ml),以注射用水为空白对照组,灌胃给药容积0.2ml/10g。用自发活动仪,分别测定第3、7、14天小鼠昼、夜12和24h自主活动总次数及第7天完成给药3h小鼠5min内自主活动次数。每组小鼠8只。结果 给药结束后3h,地西泮组5min内自主活动次数均少于各半夏组,差异有统计学意义(P<0.01,P<0.05);清半夏、生半夏、姜半夏高剂量组与各组相应的中、低剂量组及空白对照组比较,差异有统计学意义(P<0.01,P<0.05);法半夏高剂量组与空白对照组比较,差异有统计学意义(P<0.05)。第3、7天给药后,生半夏高剂量组白昼及夜间自主活动次数均少于空白对照组(P<0.05);姜半夏高剂量组在第3天白昼及第7天白昼、夜间自主活动次数均少于空白对照组,差异有统计学意义(P<0.05)。给药1周后,高、中剂量生半夏组及高剂量姜半夏组对小鼠24h的镇静作用与地西泮组比较差异无统计学意义(P>0.05)。停药1周后,高剂量生半夏组白昼自主活动次数少于空白对照组,差异有统计学意义(P<0.05)。结论 各半夏炮制品镇静作用与剂量相关,生半夏镇静效果最佳。 |
| 中文关键词:半夏 镇静 自发活动 比较 |
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| Abstract:Objective To compare different drug concentrations of different processed products of Rhizoma Pinelliae sedative effect on mice. Methods Qing Rhizoma Pinelliae, Fa Rhizoma Pinelliae, Jiang Rhizoma Pinelliae respectively according to the concentration of 0.45, 0.9, 1.8g/ml were divided into low, middle, high dose groups, while Raw Rhizoma Pinelliae concentration was 0.2, 0.4, 0.8g/ml. To settle for diazepam positive control group(0.1mg/ml), for water blank control group, both by intragastric administration. With spontaneous activity determination instrument, recording the third, seventh, fourteenth day after administration, 12 hours each day and night and 24 hours mice autonomic activities, including records of spontaneous activity of mice 5 minutes times in 7 days 3 hours after administration. Results After the administration of 3 hours after taking drug, 5 minutes independent activity frequency of diazepam group was less than the Pinellia groups, the difference had statistical significance. High dose groups of Qing Rhizoma Pinelliae, Raw Rhizoma Pinelliae and Jiang Rhizoma Pinelliae had better sedative effect than its corresponding lower dose groups and blank control group, the difference had statistical significance. The high dose group of Fa Rhizoma Pinelliae compared with the blank control group, the difference was statistically significant(P<0.05). High dose group of Raw Rhizoma Pinelliae had better sedative effect than the blank control group during day and night(P<0.05). While high dose group of Jiang Rhizoma Pinelliae had better sedative on the third day and the seventh whole day. After one week of taking drug, there was no significant difference between Raw Rhizoma Pinelliae group of middle, high dose and diazepam group on sedative effect. Jiang Rhizoma Pinelliae group of the high concentration was in the same way. One week after drug withdrawal, high dose group of Raw Rhizoma Pinelliae still had better sedative effect than the blank control group in day time. Conclusion The sedative effect of different processed products of Rhizoma Pinelliae was dose related. The Raw Rhizoma Pinelliae had the best sedative effect. |
| keywords:Rhizoma Pinelliae Sedative effect Spontaneous activity Comparation |
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