| 老年2型糖尿病合并亚临床甲状腺功能减退症患者的临床特点分析 |
| 投稿时间：2015-06-25 修订日期：2015-07-29 点此下载全文 |
| 引用本文：王娜,侯静雯,李坤,翟晨辉,侯志梅.老年2型糖尿病合并亚临床甲状腺功能减退症患者的临床特点分析[J].医学研究杂志,2016,45(2):91-94 |
| DOI：
10.11969/j.issn.1673-548X.2016.02.024 |
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| 中文摘要:目的 分析老年2型糖尿病合并亚临床甲状腺功能减退症(SCH)患者的临床特点及相关因素。方法 回顾性分析2011年3月~2014年3月新疆医科大学第二附属医院内分泌、老年病科住院,年龄≥60岁的202例糖尿病患者的临床资料。其中56例合并SCH(SCH组),146例无SCH(非SCH组),比较两组患者临床资料、生化指标等差异,采用Logistic回归分析对差异有统计学意义的指标进行多因素分析。结果 SCH组病程长于非SCH组,冠心病合并率、双胍类、他汀类的使用率高于非SCH组,SCH组TSH、FBG、HbA1c、CRP、TG、24h尿白蛋白定量、24h DBP高于非SCH组,差异均有统计学意义(P均<0.05);FT3、FT4、PBG、TC、HDL-C、LDL-C、24hSBP等指标差异均无统计学意义(P均>0.05)。Logistic多因素分析显示,病程、BMI、HbA1c、CRP、TG、尿白蛋白定量为老年2型糖尿病合并SCH的独立危险因素(OR值分别为1.140、1.374、1.947、1.113、1.419、1.044,95%CI分别为1.051~1.237、1.209~1.562、1.310~2.894、1.037~1.195、1.084~1.858、1.003~1.086),双胍类为保护因素(OR值为0.309,95%CI为0.104~0.916)。Spearman相关分析显示,病程、BMI值、FBG、HbA1c、CRP、TG、DBP与TSH呈正相关(P均<0.01),双胍类、他汀类与TSH呈负相关(P均<0.05)。结论 病程、BMI、HbA1c、CRP、TG、尿白蛋白定量可能为老年2型糖尿病合并SCH的独立危险因素,双胍类可能为保护因素。 |
| 中文关键词:2型糖尿病 老年人 亚临床甲状腺功能减退症 横断面研究 |
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| Abstract:Objective To analyze the clinical characteristics and related factors of elderly patients with type 2 diabetes and subclinical hypothyroidism(SCH). Methods A retrospective analysis was carried out on clinical data of 202 cases of diabetes patients(≥60 years old), who were inpatients from endocrine department and geriatrics department of Second Affiliated Hospital of Xinjiang Medical University between March 2011 and March 2014. 56 cases were accompanied with SCH(SCH group) while 146 cases were not(non-SCH group). Clinical data and biochemical indexes of two groups of patients were compared. Logistic regression analysis was adopted for multi-factor analysis on indexes with statistically significant differences. Results SCH group had longer disease course, higher coincidence of coronary heart disease(CHD) and higher application rate of biguanide and statin drugs than non-SCH group. SCH group had higher TSH, FBG, HbA1c, CRP, TG, 24h quantitative of urine protein and 24h DBP than non-SCH group with statistically significant differences(P all<0.05). And there were no statistically significant differences in FT3, FT4, PBG, TC, HDL-C, LDL-C and 24hSBP, etc(P all>0.05). Logistic multifactor analysis showed that disease course, BMI, HbA1c, CRP, TG and quantitative of urine protein were independent risk factors for elderly patients with type 2 diabetes and SCH(ORs were 1.140, 1.374, 1.947, 1.113, 1.419, and 1.044, respectively; 95%CI were 1.051-1.237, 1.209-1.562, 1.310-2.894, 1.037-1.195, 1.084-1.858 and 1.003-1.086); while biguanide drug was protective factor(OR was 0.309, 95%CI was 0.104-0.916). Spearman correlation analysis showed that disease course, BMI, FBG, HbA1c, CRP, TG and DBP were positively correlated with TSH(P all<0.01); while biguanide and statin drugs were negatively correlated with TSH(P all<0.05). Conclusion Disease course, BMI, HbA1c, CRP, TG and quantitative of urine protein are independent risk factors for elderly patients with type 2 diabetes and SCH while biguanide drug may be protective factor. |
| keywords:T2DM Aged Subclinical hypothyroidism Cross sectional studies |
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