| 乳腺癌中DAX-1和AR的表达及临床意义 |
| 投稿时间：2015-06-26 修订日期：2015-07-25 点此下载全文 |
| 引用本文：杨小敏,徐晓武,潘丹,陈艳梅,郑翔.乳腺癌中DAX-1和AR的表达及临床意义[J].医学研究杂志,2016,45(2):95-98 |
| DOI：
10.11969/j.issn.1673-548X.2016.02.025 |
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| 基金项目:温州市科技计划项目(Y20120063) |
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| 中文摘要:目的 检测乳腺癌中先天性肾上腺发育不良症的关键基因-l(DAX-1)和雄激素受体(AR)表达情况,探讨两者与乳腺癌各临床病理指标的关系。方法 采用免疫组化法检测DAX-1和AR在120例乳腺癌中的表达,并分析两者与临床各病理指标的关系。结果 120例乳腺癌中DAX-1和AR阳性表达率分别为75%(90/120)和75.83%(91/120)。DAX-1和AR的表达呈正相关(r=0.66,P<0.05)。DAX-1和AR的表达与肿瘤直径、组织学分级及ER和PR的表达状态有关(P<0.05),DAX-1的表达与TNM分期也有关(P<0.05),两者表达与患者年龄、月经状态、淋巴结转移情况均无关(P>0.05)。结论 乳腺癌中DAX-1和AR表达上调,两者的表达与肿瘤直径、组织学分级及ER和PR的表达状态有关,DAX-1表达与TNM分期也有关,乳腺癌中DAX-1和AR的高表达可能预示良好的预后,进一步研究两者对乳腺癌发生、发展的作用机制,可能对判断乳腺癌患者预后及提供新的内分泌辅助治疗生物学标志物有一定的帮助。 |
| 中文关键词:乳腺癌 DAX-1 AR 免疫组化 |
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| Abstract:Objective To detect the expressions of DAX-1 and AR in breast carcinoma and relationship with clinical pathological indicators. Methods The expressions of DAX-1 and AR in breast carcinoma were detceted by immunohistochemical SP method. Analyzed their relationship with clinicl pathological indicators. Results The positive rates of DAX-1 and AR were 75%(90/120) and 75.83%(91/120), respectively. There had positive correlation between DAX-1 and AR(r=0.66, P<0.05). The expressions of DAX-1 and AR were related to tumor size, histological grade, ER and PR expression status, and DAX-1 also was related to TNM stage. DAX-1 and AR expressions were not related to age, menopause and lymph node metastases. Conclusion The expressions of DAX-1 and AR are up-regulated in breast carcinoma. Their expressions have relationship with tumor size, histological grade, ER and PR expression status. And DAX-1 also has relationship with TNM stage. DAX-1 and AR high expression may indicate good prognosis. It may has help for judging prognosis and providing newadjuvant endocrine therapy biomarker for the patients with breast cancer to make further efforts on mechanism of action about DAX-1 and AR. |
| keywords:Breast cancer DAX-1 AR Immunohistochemical |
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