宁波地区幽门螺杆菌现症感染人群缺铁性贫血指标特点和原因分析
投稿时间:2015-06-14  修订日期:2015-07-19  点此下载全文
引用本文:王峰,汪丽,李静杰,黄诗良.宁波地区幽门螺杆菌现症感染人群缺铁性贫血指标特点和原因分析[J].医学研究杂志,2016,45(2):104-107
DOI: 10.11969/j.issn.1673-548X.2016.02.027
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作者单位
王峰 315040 宁波市医疗中心李惠利医院 
汪丽 315040 宁波大学医学院附属医院 
李静杰 315040 宁波市医疗中心李惠利医院 
黄诗良 315040 宁波市医疗中心李惠利医院 
中文摘要:目的 调查宁波地区体检人群幽门螺杆菌(Hp)现症感染与缺铁性贫血相关指标的关系,并对Hp现症感染致贫血因素进行分析。方法 选取宁波市医疗中心李惠利医院体检中心2014年10月~2015年3月经幽门螺杆菌IgG抗体(含现症感染蛋白抗体)检测试剂盒(ASSURE H.Pylori Rapid Test)测定的体检人员1470例,分别用相应检验方法对血红蛋白(Hb)、平均红细胞体积(MCV)、平均血红蛋白浓度(MCHC)、血清铁(SI)、血清铁蛋白(SF)、未结合铁(UIBC)、总铁结合力(TIBC)等贫血相关指标进行了检测,对该人群不同性别和年龄段间相关检测指标进行分析。结果 男性Hp现症感染者MCV值大于非现症感染者,而MCHC同比更低(P均<0.05);女性Hp现症感染阳性同阴性人群比较,表现为Hb和SI较低(P<0.05)。按年龄段进一步分析发现,男性30岁以下Hp现症感染者MCHC低于未感染者,其他年龄段差异无统计学意义(P>0.05);女性Hp现症感染阳性人群表现为31~40岁年龄段SF低于未感染者,而41~50岁年龄段MCHC、SI、SF均更低(P<0.05),其他年龄段差异无统计学意义(P>0.05)。结论 宁波地区体检人群中Hp现症感染与缺铁性贫血存在一定关系,并表现了年龄段间不同程度的差异,定期进行Hp现症感染评估及进行贫血相关指标检测对慢性胃病的诊疗有重要意义。
中文关键词:缺铁性贫血  幽门螺杆菌  血液学实验  胃部疾病
 
Abstract:Objective To study the relationship between Helicobacter pylori(H.pylori) current infection and IDA-related indicators in Ningbo physical examination people, and to analyze the causes. Methods Totally 1470 cases were enrolled in the study from October 8th 2014 to March 24th 2015, which underwent Helicobacter pylori IgG antibody detection(ASSURE H.Pylori Rapid Test).And hemoglobin(Hb), mean corpuscular volume(MCV), mean hemoglobin concentration(MCHC), serum iron(SI), serum ferritin(SF), unsaturated iron binding force(UIBC), total iron binding force anemia(TIBC), and other related indexes were detected by the corresponding testing method.SPSS software was used to analyze the data. Results Analysis showed that the Hp positive males were accompanied with the higher MCV values, and lower MCHC, compared with negative populations(P<0.05). Hp current infected females who compared negative ones were characterized by lower Hb and SI(P<0.05). According to age group, further results showed that MCHC was lower than uninfected in the Hp current infected men under 30-year-old, and other age groups had no significant difference.For Hp positive females, lower SF was found in the age group of 31-40, while MCHC, SI, SF were reduced for 41-50 year-old group(P<0.05).No differences were showed in other age groups. Conclusion There is some relationship between Hp infection and IDA-related indicators in adults in Ningbo area, and the results show a different degree among different age groups.Evaluating Hp current infection status regularly and examining anemia-related indicators may have important implication for diagnosis and treatment of chronic gastric diseases.
keywords:Iron-deficiency anemia  Helicobacter pylori  Hematologic tests  Gastric diseases
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