| 比较两种丙泊酚制剂对儿童肝脏功能及甘油三酯水平的影响 |
| 投稿时间：2015-07-18 修订日期：2015-07-21 点此下载全文 |
| 引用本文：曹冬冬,蔡丽敏,张媛,韩伟.比较两种丙泊酚制剂对儿童肝脏功能及甘油三酯水平的影响[J].医学研究杂志,2016,45(2):113-115 |
| DOI：
10.11969/j.issn.1673-548X.2016.02.029 |
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| 中文摘要:目的 比较短时间持续输注丙泊酚长链脂肪乳和丙泊酚中/长链脂肪乳对儿童肝脏功能及甘油三酯水平的影响。方法 选择择期行扁桃体、腺样体切除术的儿童患者60例,患儿年龄4~12岁,ASA Ⅰ~Ⅱ级。将患儿随机分为A、B两组,每组30例。A组使用AstraZeneca UK Limited厂家生产的丙泊酚长链脂肪乳(得普利麻,规格50ml/500mg),B组使用Fresenius Kabi Deutschland GmbH厂家生产的丙泊酚中/长链脂肪乳(竞安,规格20ml/200mg)。分别在麻醉诱导前(T0)、手术结束时(T1)和手术结束后4h(T2)抽取静脉血,检测甘油三酯(TG)、谷丙转氨酶(ALT)、谷草转氨酶(AST)、血清淀粉酶(AMY)含量。结果 与T0时比较,A组在T1、T2时的TG值和AMY值明显上升(P<0.05),B组在T1、T2时的AMY值明显上升(P<0.05),在T1时的TG值明显上升(P<0.05),在T2时的TG值与T0时比较未见明显变化(P>0.05)。与T0时比较,A、B两组在T1、T2时的ALT、AST值未见明显变化(P>0.05)。结论 短时间持续静脉输注丙泊酚长链脂肪乳和丙泊酚中/长链脂肪乳均使儿童的甘油三酯和血清淀粉酶水平升高。与丙泊酚长链脂肪乳相比较,丙泊酚中/长链脂肪乳对血浆甘油三酯水平的影响更小,在术后的代谢更快,更适合应用于儿童短时间手术的麻醉。 |
| 中文关键词:丙泊酚 儿童 甘油三酯 肝脏功能 血清淀粉酶 |
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| Abstract:Objective To compare the effect of propofol in long chain triglyceride(LCT) and propofol in medium and long chain triglyceride(MCT-LCT) on hepatic function and serum triglyceride level in pediatric patients in general anesthesia. Methods A total of 60 children(age 4-12, ASA Ⅰ-Ⅱ), who underwent selective tonsillectomy and adenoidectomy were randomized into two groups of 30 each. Group A were induced and maintained with 1% LCT propofol(50ml/500mg), while Group B with 1% MCT-LCT propofol(20ml/200mg). Blood samples for triglyceride(TG), alanine aminotransferase(ALT), aspartate aminotrasferase(AST), and amylase(AMY) were obtained before anesthesia induction T0, at the end of operation T1, and 4 hours after the end of surgery T2. Results AMY levels rose significantly above the basal levels in both Group A and Group B(P<0.05).TG levels rose above the basal levels at the end of operation T1(P<0.05)and kept rising 4 hours after the end of surgery T2(P<0.05)in Group A. TG levels rose above the basal levels at the end of operation T1(P<0.05), while fell back to the basal levels 4 hours after the end of surgery T2(P>0.05)in Group B. There was no statistical difference in ALT and AST value among three time points(P>0.05). Conclusion Even short-term anesthesia with LCT and MCT-LCT propofol(1%) leads to elevated TG and AMY levels. The increase of TG levels in serum is less with MCT-LCT propofol and elimination of TG is also rapid after terminating MCT-LCT propofol infusion.The MCT-LCT propofol is more suitable for pediatric patients in short-term anesthesia. |
| keywords:Propofol Pediatric Triglyceride Hepatic function Amylase |
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