| 去除颈动脉窦和损伤POA对AVP引起大鼠低温的影响 |
| 投稿时间：2015-09-29 修订日期：2015-10-09 点此下载全文 |
| 引用本文：陈冰,沈字玲,杨永录,熊资,卜舒.去除颈动脉窦和损伤POA对AVP引起大鼠低温的影响[J].医学研究杂志,2016,45(3):70-73 |
| DOI：
10.11969/j.issn.1673-548X.2016.03.019 |
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| 基金项目:四川省教育厅科研基金资助项目(12ZB204);四川省卫生厅科研基金资助项目(120495);成都医学院学科建设项目专项基金资助项目(CYXK2012003) |
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| 中文摘要:目的 观察去除颈动脉窦和损伤下丘脑视前区(POA)对外周给精氨酸加压素(AVP)引起大鼠低温的影响.方法 实验用成年雄性SD大鼠,去除颈动脉窦或用卡因酸损伤POA.在22℃环境中,用无线遥控测温技术连续记录大鼠体温和活动的变化,10∶ 00 AM给大鼠腹腔注射AVP(10μg/kg)或生理盐水(等容量).结果 去除颈动脉窦能明显减弱腹腔注射AVP引起低温反应(-1.26±0.32℃),与假手术大鼠降温效应(-1.95±0.22℃)比较差异有统计学意义(P<0.01).损伤POA大鼠,腹腔注射AVP引起的低温反应幅度(-0.8±0.17℃)明显小于假手术大鼠(-1.56±0.22℃,P<0.01).结论 去除颈动脉窦和损伤POA均能够减弱腹腔注射AVP引起的低温反应,提示颈动脉窦压力感受器和POA参与外周给AVP引起的低温反应. |
| 中文关键词:精氨酸加压素 低温 下丘脑视前区 颈动脉窦压力感受器 |
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| Effect of Sinoaortic Denervation and Preoptic Area Lesioned on AVP-induced Hypothermia in Rats. |
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| Abstract:Objective To observe the effect of sinoaortic denervation (SAD) and preoptic area (POA) lesioned on arginine vasopressin(AVP)-induced hypothermia in rats. Methods Male Sprague-Dawley rats were submitted to sinoaortic denervation or kainic acid lesioning of the POA. Core temperature and motor activity were monitored by telemetry at an ambient temperature of 22℃. Rats were dosed intraperitoneally at 10∶ 00 with AVP (10μg/kg) or saline (the same volume). Results Sinoaortic denervation (SAD) significantly prevented hypothermia induced by intraperitoneal injection of AVP when compared to sham rats (-1.26±0.32℃ AVP-SAD vs -1.95±0.22℃ AVP-sham, P<0.01). POA lesioned rats treated with AVP had a attenuated decrease in core temperature to sham rats (-0.8±0.17℃ AVP-POA lesioned vs -1.56±0.22℃ AVP-sham, P<0.01). Conclusion Sinoaortic denervation and POA lesioned attenuated hypothermia induced by intraperitoneal injection of AVP, suggesting that sinoaortic baroreceptors and POA would involve in the hypothermic effect of peripheral vasopressin. |
| keywords:Arginine vasopressin Hypothermia Preoptic area Sinoaortic baroreceptors |
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