季节变化和光周期性对体外受精胚胎移植结局的影响
投稿时间:2015-08-18  修订日期:2015-09-10  点此下载全文
引用本文:凌超,葛红山,卢晓声,陈华,朱春芳,习海涛,张帆,吕杰强.季节变化和光周期性对体外受精胚胎移植结局的影响[J].医学研究杂志,2016,45(3):73-76,82
DOI: 10.11969/j.issn.1673-548X.2016.03.020
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作者单位E-mail
凌超 325000 温州医科大学  
葛红山 325000 温州医科大学附属第二医院生殖中心  
卢晓声 325000 温州医科大学附属第二医院生殖中心  
陈华 325000 温州医科大学附属第二医院生殖中心  
朱春芳 325000 温州医科大学附属第二医院生殖中心  
习海涛 325000 温州医科大学附属第二医院生殖中心  
张帆 325000 温州医科大学附属第二医院生殖中心  
吕杰强 325000 温州医科大学
325000 温州医科大学附属第二医院生殖中心 
jieqianglu@126.com 
基金项目:浙江省自然科学基金资助项目(青年项目)(LQ12H04001);浙江省卫生厅一般项目(2013KYB173)
中文摘要:目的 探讨季节变化和光周期性对体外受精(IVF)或单精子胞质内注射(ICSI)-胚胎移植(ET)治疗结局的影响.方法 回顾性分析首次行IVF/ICSI-ET治疗、年龄<38岁、体重指数(BMI)<25kg/m2、采用黄体期长方案超排卵及取卵后第3天行新鲜胚胎移植的1222例患者的临床资料.根据取卵日期将其分为春、夏、秋、冬组,或长、短日照期组,比较各季节组间及长、短日照期组间优胚率、种植率和临床妊娠率等的差异.结果 各季节组间及长、短日照期组间,患者的年龄、体重指数、不孕时间、基础FSH值和不孕因素的构成差异均无统计学意义(P>0.05);卵巢反应性、HCG日子宫内膜厚度、成熟卵率、正常受精率(2PN率)、卵裂率、优胚率和移植胚胎数等指标差异均无统计学意义(P>0.05).各季节组间患者的HCG阳性率、种植率和临床妊娠率差异亦无统计学意义(P>0.05);但长日照期组患者的种植率和临床妊娠率高于短日照期组,差异有统计学意义(P<0.05).结论 季节变化对IVF/ICSI治疗结局无明显影响,但长日照期IVF/ICSI周期较短日照期可以获得更好的临床结局.
中文关键词:季节性  光周期性  体外受精  卵母细胞胞质内单精子注射
 
Influence of Seasonal Variation and Photoperiodism on the Outcome of IVF/ICSI-ET.
Abstract:Objective evaluate the effects of seasonality and photoperiodism on the outcomes of IVF/ICSI-ET treatment cycles. Methods The data of 1222 infertile women undergoing their first IVF/ICSI cycles were collected retrospectively. Patient's characteristics were summarized as age<38years old, BMI<25kg/m2, long protocol for ovulation and transferred on D3 embryo. Patients were assigned to season groups, or long/short daytime groups according to the day of oocyte retrieval. The general clinical character and clinical outcomes were compared. Results There was no significant difference in the average age, BMI, infertility duration, basal FSH level or the proportion of infertility factors between season groups, or long/short daytime groups (P>0.05). And ovarian response, oocytes maturation rates, 2PN rates, cleavage rates, high-quality embryo rates, the number of embryos transferred were also similar (P>0.05). The HCG positive rate, implantation rate and clinical pregnancy rate between season groups also did not show statistical significant difference (P>0.05). However, long daytime group had a higher implantation rate and clinical pregnancy rate than short daytime group (P<0.05). Conclusion Seasonality does not affect IVF/ICSI cycles. Increased length of daylight may benefit the outcomes of IVF/ICSI cycles.
keywords:Seasonality  Photoperiodism  In vitro fertilization(IVF)  Intracytoplasmic sperm injection(ICSI)
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