机械辅助动脉溶栓联合脑心通胶囊治疗急性缺血性脑卒中的临床疗效研究
投稿时间:2015-07-13  修订日期:2015-08-03  点此下载全文
引用本文:傅攀,朱碧宏.机械辅助动脉溶栓联合脑心通胶囊治疗急性缺血性脑卒中的临床疗效研究[J].医学研究杂志,2016,45(3):146-149
DOI: 10.11969/j.issn.1673-548X.2016.03.038
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作者单位
傅攀 318020 台州市第一人民医院神经内科 
朱碧宏 318020 台州市第一人民医院神经内科 
中文摘要:目的 观察机械辅助动脉溶栓联合脑心通胶囊对急性缺血性脑卒中(AIS)的临床疗效,并探讨相关机制.方法 收集笔者医院神经内科2013年4月~2015年2月收治的行机械辅助动脉溶栓治疗的AIS患者80例,分为机械辅助动脉溶栓对照组和机械辅助动脉溶栓联合脑心通胶囊治疗组,每组40例.脑梗死溶栓分级(TICI)评价血管再通情况,美国国立卫生研究院脑卒中(NIHSS)量表、格拉斯哥昏迷量表(GCS)评分、Fugl Meyer运动功能(FMA)量表和躯干控制(Sheikh)量表评价近远期神经损伤.ELISA法检测8-异前列腺素F(8-iso-PGF)和白介素-6(IL-6)表达.结果 对照组血管再通率为82.5%,治疗组血管再通率为85.0%,两组间差异无统计学意义(P>0.05).两组治疗前NIHSS和GCS评分差异无统计学意义(P>0.05),治疗1周后NIHSS评分两组均出现显著减低(P<0.05),GCS评分均出现显著升高(P<0.05),但治疗1周后NIHSS和GCS评分两组间差异无统计学意义(P>0.05).治疗前FMA和Sheikh评分两组间差异无统计学意义(P>0.05),治疗3个月后FMA和Sheikh评分两组均显著升高(P<0.01),但治疗组FMA和Sheikh评分高于对照组(P<0.05).治疗前8-iso-PGF和IL-6因子表达两组间差异无统计学意义(P>0.05),治疗1周后8-iso-PGF和IL-6因子表达两组均显著减低(P<0.05和P<0.01),但治疗组8-iso-PGF和IL-6因子表达低于对照组(P<0.05).结论 机械辅助动脉溶栓联合脑心通胶囊可显著减轻急性缺血性脑卒中患者氧化应激损伤,有利于患者远期神经功能的恢复.
中文关键词:机械辅助动脉溶栓  脑心通胶囊  急性缺血性脑卒中  氧化应激损伤
 
Clinical Efficacy of Mechanical Embolus Disruption Combined with Naoxintong Capsules in Acute Ischemic Stroke Patients.
Abstract:Objective To investigate the effect of mechanical embolus disruption combined with Naoxintong Capsules on acute ischemic stroke(AIS) patients and explore the mechanism. Methods A total of 80 AIS patients with mechanical embolus disruption were enrolled in this study. Patients were divided into mechanical embolus disruption control group and mechanical embolus disruption combined with Naoxintong Capsules treatment group. TICI was used to estimate the success of recanalization. NIHSS, GCS, FMA, and Sheikh scores were used to estimate nerve function injury. 8-iso-PGF and IL-6 expression was detected by ELISA analysis. Results The rate of recanalization was 82.55 in control group, and 85.0% in treatment group. There was no significant difference between the two groups (P>0.05). After treatment for 1 week, the NIHSS scores were increased and GCS scores were decreased in the two groups(P<0.05). There was no significant difference between the two groups (P>0.05). After treatment for 3 monthes, the FMA and Sheikh scorse were increased in the two groups(P<0.01). There was significant difference between the two groups (P<0.05). After treatment for 1 week, 8-iso-PGF and IL-6 expression was decreased in the two groups(P<0.05), which was lower in control group than that in treatment group (P<0.05). Conclusion Mechanical embolus disruption combined with Naoxintong Capsules could significantly reduce oxidative stress damage in AIS patients and was contribute to long-term recovery of nerve function injury.
keywords:Mechanical embolus disruption  Naoxintong capsule  Acute ischemic stroke(AIS)  Oxidative damage
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