| 盘状红斑狼疮患者维生素D水平改变及补充维生素D的治疗效果 |
| 投稿时间：2015-04-24 修订日期：2015-06-12 点此下载全文 |
| 引用本文：朱林,郑招云,张炳权.盘状红斑狼疮患者维生素D水平改变及补充维生素D的治疗效果[J].医学研究杂志,2016,45(3):170-173 |
| DOI：
10.11969/j.issn.1673-548X.2016.03.045 |
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| 中文摘要:目的 探讨盘状红斑狼疮(DLE)患者维生素D水平的改变,以及补充维生素D治疗DLE的效果.方法 以50例DLE患者和性别、年龄相匹配的健康查体者50例为研究对象,检测维生素D水平.将维生素D水平缺乏或不足的患者随机分为治疗组和对照组,分别给予维生素D和安慰剂3个月.记录两组患者的基线和干预后CLASI评分、TNF-α和IL-2水平.结果 DLE患者25(OH)D水平显著低于健康查体者.经3个月的干预后,治疗组25(OH)D、TNF-α、IL-2和CLASI活动度评分与干预前、对照组干预后相比差异有统计学意义.结论 DLE患者多存在维生素D不足或缺乏,补充维生素D能够降低疾病活动度. |
| 中文关键词:盘状红斑狼疮 维生素D 皮肤型红斑狼疮疾病面积和严重程度指数 |
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| Change of Vitamin D Level in Patients with Discoid Lupus Erythematosus and the Therapeutic Effect of Vitamin D Supplementation. |
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| Abstract:Objective To explore the change of vitamin D level in patients with discoid lupus erythematosus (DLE) and the therapeutic effect of vitamin D supplementation. Methods Fifty cases of DLE patients and 50 cases of age-and sex-matched healthy subjects were included. Vitamin D levels were detected in all subjects. Patients who were lack or insufficient in vitamin D levels were randomly divided into treatment group and control group, and they were given vitamin D and placebo for three months, respectively. CLASI score, TNF-α and IL-2 levels at baseline and post-intervention were recorded in 2 groups of patients. Results Compared to healthy people, DLE patients had a significantly lower 25 (OH) D level. The level of 25 (OH) D, TNF-α, IL-2 and CLASI activity score after 3 months of intervention in the treatment group were significantly different than before intervention and the control group after intervention. Conclusion DLE patients often show vitamin D deficiency or lack, and vitamin D supplementation can reduce disease activity. |
| keywords:Discoid lupus erythematosus Vitamin D Cutaneous lupus erythematosus disease area and severity index |
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