| 促红细胞生成素对大鼠脊髓损伤后神经生长蛋白43和微管相关蛋白-2表达的影响 |
| 投稿时间：2015-11-05 修订日期：2015-11-17 点此下载全文 |
| 引用本文：王宁,徐纪伟,刘红敏,华新宇.促红细胞生成素对大鼠脊髓损伤后神经生长蛋白43和微管相关蛋白-2表达的影响[J].医学研究杂志,2016,45(5):104-107 |
| DOI：
10.11969/j.issn.1673-548X.2016.05.025 |
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| 基金项目:河南省教育厅自然科学基金资助项目(13B310163) |
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| 中文摘要:目的 观察促红细胞生成素(erythropoietin,EPO)对大鼠脊髓损伤(spinal cord injury,SCI)的保护作用及神经细胞神经生长蛋白43(GAP-43)、微管相关蛋白-2(MAP-2)表达的影响。方法 制作SCI模型,分为假手术组、生理盐水组、EPO治疗组。用免疫组织化学染色方法检测神经细胞内GAP-43和MAP-2的表达变化,同时通过BBB运动评分检测动物的运动功能。结果 EPO治疗组较生理盐水组GAP-43和MAP-2表达水平高,EPO治疗组的BBB运动评分明显优于生理盐水组。结论 EPO能够通过增加GAP-43和MAP-2表达,促进神经细胞生长。 |
| 中文关键词:促红细胞生成素 脊髓损伤 神经细胞神经生长蛋白43 微管相关蛋白-2 |
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| Effect of Erythropoietin on GAP-43 and MAP-2 Expression After Spinal Cord Injury in Rats |
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| Abstract:Objective To investigate the effect of Erythropoietin on GAP-43 and MAP-2 expression after spinal cord injury in rats. Methods Rats were randomly divided into sham group, NS group and erythropoietin treated group. Immunohistochemistry staining was used to observe GAP-43 and MAP-2 expression. BBB test were used to observe motor function in rats. Results Curcumin treatment group compared with NS group, GAP-43 and MAP-2 expression were significantly increased. The score of BBB test Erythropoietin treatment group were significantly better than NS group. Conclusion Erythropoietin might promote neurons growth by GAP-43 and MAP-2. |
| keywords:Erythropoietin Spinal cord iniury GAP-43 MAP-2 |
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