| 常用血清肿瘤标志物对腹膜假黏液瘤诊断价值的初步探讨 |
| 投稿时间：2015-10-23 修订日期：2015-10-30 点此下载全文 |
| 引用本文：宋燕,何美琳,邵冬华,梁国威.常用血清肿瘤标志物对腹膜假黏液瘤诊断价值的初步探讨[J].医学研究杂志,2016,45(5):126-129 |
| DOI：
10.11969/j.issn.1673-548X.2016.05.031 |
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| 基金项目:航天中心医院院内课题(YN201321) |
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| 中文摘要:目的 初步探讨常用血清肿瘤标志物癌胚抗原(carcinoembryonic antigen,CEA)、糖类抗原125(carbohydrate antigen 125,CA125)、糖类抗原199(carbohydrate antigen 199,CA199)、糖类抗原724(carbohydrate antigen 724,CA724)和糖类抗原242(carbohydrate antigen 242,CA242)对初诊腹膜假黏液瘤的诊断价值。方法 研究对象包括28例经病理确诊的腹膜假黏液瘤患者,23例肠梗阻、肠炎等良性腹部疾病患者及29例健康体检者,应用化学发光法测定上述3组研究对象血清中CEA、CA125、CA199、CA724和CA242的含量,分析其在3组研究对象血清中的表达情况,采用ROC曲线分析各检测项目对腹膜假黏液瘤的敏感度和特异性。结果 腹膜假黏液瘤患者血清中5种肿瘤标志物的表达水平显著高于良性疾病组和健康对照组(P均<0.05),其中CEA、CA125、CA199、CA724和CA242对疾病的敏感度分别是89.3%、89.3%、78.6%、92.9%和89.3%,特异性分别为100.0%、98.1%、98.1%、92.3%和98.1%,曲线下面积分别为0.945、0.942、0.875、0.966和0.954。将5种肿瘤标志物联合检测,发现该组合对腹膜假黏液瘤诊断的敏感度为100.0%,特异性为80.8%,阳性预测值为73.7%,阴性预测值为100%。结论 5种肿瘤标志物联合检测对腹膜假黏液瘤诊断的敏感度高于单个肿瘤标志物,且联合检测对疾病的阴性预测值可达100%,该组合可辅助临床对非黏液瘤患者做出排除诊断。 |
| 中文关键词:腹膜假黏液瘤 肿瘤标志物 ROC曲线 |
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| Investigation on the Diagnosis Value of Serum Tumor Markers in Patients with Pseudomyxoma Peritonei |
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| Abstract:Objective To investigate the clinical value of serum CEA, CA125, CA199, CA724 and CA242 in patients with Pseudomyxoma peritonei (PMP). Methods Expression of CEA, CA125, CA199, CA724 and CA242 in 28 cases of PMP, 23 cases with benign abdominal diseases and 29 health adults was detected by the technology of chemiluminescence. ROC curve was applied to analyze the sensitivity and specificity of tumor markers. Results Expression of serum CEA, CA125,CA199, CA724 and CA242 was significantly higher in PMP patients than those in benign abdominal disease group and control group (P<0.05). Sensitivity of CEA, CA125, CA199, CA724 and CA242 were 89.3%, 89.3%, 78.6%, 92.9% and 89.3%, while specificity were 100.0%, 98.1%, 98.1%, 92.3% and 98.1%. Area under curve were 0.945, 0.942, 0.875, 0.967 and 0.954. The combination of CEA, CA125, CA199, CA724 and CA242 was more appropriate than single tumor marker, and sensitivity, specificity, positive and negative predictive value of the combination were 100.0%, 80.8%, 73.7% and 100.0%, respectively. Conclusion Combination of CEA, CA125, CA199, CA724 and CA242 was more useful in diagnosis of PMP than single tumor marker, while sensitivity and negative predictive value of the combination were 100%, which means PMP could be excluded while the result of combined tumor markers was negative. |
| keywords:Pseudomyxoma peritonei Tumor marker ROC curve |
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