体检人群血脂异常分型与骨密度的相关性研究
投稿时间:2015-12-01  修订日期:2015-12-15  点此下载全文
引用本文:洪剑鑫,陈海啸,朱敏.体检人群血脂异常分型与骨密度的相关性研究[J].医学研究杂志,2016,45(6):83-86,93
DOI: 10.11969/j.issn.1673-548X.2016.06.021
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作者单位E-mail
洪剑鑫 317000 临海, 温州医科大学附属台州医院 xs_hongjx@163.com 
陈海啸 317000 临海, 温州医科大学附属台州医院  
朱敏 317000 临海, 温州医科大学附属台州医院  
基金项目:浙江省自然科学基金资助项目(LY16H070008)
中文摘要:目的 比较分析体检人群中不同血脂异常分型者骨密度及骨量分布水平的差异,探究血脂增高对骨密度的影响。方法 入选空腹血糖正常(FPG<6.1mmol/L)的体检者331例,患者年龄50~75(59.81±7.91)岁,依据空腹血脂水平将体检者分为4组:胆固醇与甘油三酯混合增高组(以下简称为混合组,99例)、高胆固醇组(100例)、高甘油三酯组(44例),以及血脂正常型对照组(以下简称为对照组,88例)。收集上述体检者基本信息、生化指标以及腰1~4椎体平均骨密度与T值等数据,应用统计学方法比较分析各组之间骨密度、骨量分布水平等情况的差异。结果 混合组、高胆固醇组的骨密度分别为0.977±0.143g/cm2、0.979±0.149g/cm2,均低于对照组的骨密度(1.044±0.161g/cm2P均=0.03);高甘油三酯组的骨密度为1.021±0.137g/cm2,与对照组的骨密度相比差异无统计学意义(P=0.409);混合组、高胆固醇组的骨量异常比率(T值<-1.0)均高于对照组,P值分别为0.012、0.004;高甘油三酯组的骨量异常比例与对照组相比差异无统计学意义(P=0.267)。结论 体检人群中血脂增高者骨密度低于血脂正常者骨密度的可能性较大,尤其要注意混合型和高胆固醇型血脂增高者的骨密度筛查,以利于有关人群中骨量减少的早期发现和骨质疏松的早期预防。
中文关键词:血脂增高  骨密度  骨质疏松  骨量减少
 
Correlation Study of Different Dyslipidemia Classification and Bone Mineral Density in Health-examinees
Abstract:Objective To compare and analyze the discrepancy of bone mineral density and bone mass distribution in health-examinees which are divided into different dyslipidemia classification,and to explore the effect of increased blood lipid on bone mineral density. Methods In this study, 331 health-examinees with normal fasting plasma glucose (FPG<6.1mmol/L),aged 50-75 (59.81±7.91), were divided into 4 groups according to fasting serum lipid levels: combined dyslipidemic group (Combined group, 99 cases), hypercholesterolemic group (HCh group, 100 cases),hypertriglyceridemic group (HTG group, 44 cases) and control group (88 cases). We collected the basic information, biochemical indicators and 1-4 average lumbar bone mineral density and T values. Statistical method was applied to analyze the discrepancies of bone mineral density, bone mass distribution, and so on among different groups. Results The bone mineral density of the combined group (0.977±0.143g/cm2) and the HCh group (0.979±0.149g/cm2) were lower than the control group (1.044±0.161g/cm2,P values were 0.03 both). The bone mineral density of HTG group (1.021±0.137g/cm2) had no statistical differences compared with Control group (P=0.409). The bone mass abnormal proportion of combined group and HCh group were higher than the Control group both,and P values were 0.012 and 0.004. Abnormal bone mass ratio in HTC group had no statistical discrepancy compared with Control group (P=0.267). Conclusion In health-examinees, the bone mineral density of hyperlipidemia was likely to lower than the normal. Therefore, the attention of bone mineral density screening should be paid to the hyperlipidemia, in order to facilitate the early detection of osteopenia and the early prevention of osteoporosis.
keywords:Hyperlipidemia  Bone mineral density  Osteopenia  Osteoporosis
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