| Abstract:Objective To observe the effect of intratympanic injection of mouse nerve growth factor combined with prednisolone for sudden ear. Methods Totally 124 cases of sudden deafness were randomly divided into two groups.Patients in observation group was done by intratympanic injection with 0.5ml mouse nerve growth factor(18μg) combined with prednisolone(20mg) for 2 weeks,once 3 days.Those in the control group were treated by intramuscular injection of nerve growth factor 18μg, prednisolone 20mg for two weeks, once every two day. The clinical efficacy of the two groups were observed, and IL-10, NO, SOD, Hs-CRP level in serum of 7 days and 14 days was compared. Results The total effective rate in the observation group was significantly better than that in the control group (P<0.05). After treatment with 7 days and 14 days, the Hs-CRP of the two groups were significantly decreased (P<0.05), and IL-10, SOD, NO were significantly increased (P<0.05). Especially in the observation group after treatment, Hs-CRP, IL-10, NO, SOD level e was statistically significant than those of the control group, the differenc (P<0.05). Conclusion Intratympanic injection of mouse nerve growth factor and prednisolone in treatment of sudden deafness is effective, which can effectively improve the deafness, tinnitus and vertigo, improved the level of inflammation and oxidative stress. It is worth clinical promotion. |
