| 早期子宫内膜癌患者保留卵巢的可行性分析 |
| 投稿时间：2016-01-19 修订日期：2016-03-04 点此下载全文 |
| 引用本文：王霞,吴玉梅.早期子宫内膜癌患者保留卵巢的可行性分析[J].医学研究杂志,2016,45(7):59-62 |
| DOI：
10.11969/j.issn.1673-548X.2016.07.017 |
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| 基金项目:北京市卫生局首发基金资助项目（2011-2011-03）；北京市科委重点基金资助项目（D131100005313009） |
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| 中文摘要:目的 观察45岁以下Ⅰ期子宫内膜癌患者保留卵巢的预后和卵巢功能，探讨年轻子宫内膜癌患者保留卵巢的可行性。方法 101例年龄≤45岁Ⅰ期子宫内膜癌患者均行手术治疗，所有入组患者术前均予以知情，根据患者自愿分为保留卵巢组25例（实验组）和切除卵巢组76例（对照组），观察两组的临床治疗效果。结果 两组的无瘤生存期及健康指数评分（EQ-5D健康指数表）差异无统计学意义，但实验组术后性生活质量显著优于对照组（P<0.05），性激素水平也明显优于对照组（FSH，LH以及E2为观察指标），差异有统计学意义（P<0.05）。结论 对于年轻早期子宫内膜癌患者，手术保留卵巢具有可行性，能够保留其内分泌功能，有效提高患者的生活质量。 |
| 中文关键词:子宫内膜癌|卵巢功能|生活质量 |
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| Analysis of the Feasibility of Ovary Conservation in Patients with Early Stage Endometrial Carcinoma |
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| Abstract:Objective The prognosis and ovarian function of patients under the age of 45 who had ovary conservation with stage Ⅰ endometrial cancer (EC) were observed, to investigate the feasibility of ovary conservation. Methods Totally 101 patients aged 45 or younger with stage Ⅰ endometrial cancer underwent surgical treatment. The recruited patients were all informed preoperatively, and were divided into two groups according to their voluntary:reserved ovaries group of 25 cases (experimental group) and resection group of 76 cases (control group). The clinical therapeutic effect of two groups was observed. Results There was no significant difference between the two groups in the disease-free survival and the health index score (EQ-5D), but the quality of sexual life in ovary reserved group was significantly higher than that in the ovariectomized group (P<0.05); the level of sex hormones in the experimental group was significantly better than that in the control group (LH, FSH and E2 as the observation index) with statistical significance (P<0.05). Conclusion Ovarian preservation in operation is safe and feasible for stage I EC patients under the age of 45. This method can preserve their reproduction and endocrine function, and it can effectively improve their quality of life. |
| keywords:Endometrial cancer|Ovarian function|Quality of life |
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