| 高效抗反转录病毒治疗(HAART)对艾滋病患者血清炎性标志物水平影响研究 |
| 投稿时间：2015-11-18 修订日期：2015-12-23 点此下载全文 |
| 引用本文：冯润川,黄绍标,覃英梅,苏国生.高效抗反转录病毒治疗(HAART)对艾滋病患者血清炎性标志物水平影响研究[J].医学研究杂志,2016,45(7):156-159 |
| DOI：
10.11969/j.issn.1673-548X.2016.07.042 |
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| 中文摘要:目的 观察艾滋病患者高效抗反转录病毒治疗（HAART）对其血清炎性标志物（TNF-α、Ang-Ⅱ、hs-CRP）水平影响，并与正常人水平比较。方法 监测36例HIV/AIDS患者（观察组）接受高效抗反转录病毒治疗（HAART）前和治疗后（6、12个月）的血清高敏C反应蛋白（high sensitive C-reactive protein，hs-CRP）、肿瘤坏死因子（tumor necrosis factor，TNF-α）、血管紧张素-Ⅱ（angiotensin Ⅱ，Ang-Ⅱ）水平，并与36例健康体检者（对照组）相应血清炎性标志物比较。以流式细胞计数法检测CD4+ T细胞数、CD4+ T/CD8+ T值。结果 AIDS接受HAART组治疗前、治疗后6、12个月及正常人静脉hs-CRP、TNF-α、Ang-Ⅱ水平分别为7.37±1.55ml/L，0.75±0.24ng/L，97.2±7.6pg/L、4.65±1.48ml/L，0.48±0.20ng/L，90.0±8.2pg/L、3.82±1.45ml/L，0.40±0.16ng/L，87.2±7.4pg/L和2.68±1.08ml/L，0.32±0.16ng/L，64.2±10.5pg/L。与治疗前比较，治疗6、12个月后的hs-CRP、TNF-α、Ang-Ⅱ水平均有明显降低（P均<0.05）；CD4+ T细胞数、CD4+ T/CD8+ T比值升高。结论 高效抗反转录病毒治疗可以降低艾滋病患者血清hs-CRP、TNF-α、Ang-Ⅱ等炎性指标水平，提高机体免疫系统功能，控制艾滋病疾病发展。 |
| 中文关键词:艾滋病|高效抗反转录病毒治疗|高敏C反应蛋白|肿瘤坏死因子|血管紧张素-Ⅱ |
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| Effect of Inflammatory Markers Level on the AIDS Patients' Serum Impacted by Highly Active Antiretroviral Therapy |
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| Abstract:Objective To observe the effect of highly active antiretroviral therapy (HAART) on the levels of serum inflammatory markers (TNF-α、Ang-Ⅱ、hs-CRP) in AIDS patients, and compare with the normal levels. Methods Monitoring 36 cases of HIV/AIDS patients(observation group) received highly active antiretroviral therapy (HAART) before and after treatment(6 and 12 months) of serum high sensitive C-reactive protein(hs-CRP),tumor necrosis factor(TNF-α) and angiotensin Ⅱ(Ang-Ⅱ) levels, and with 36 healthy volunteers(control group) corresponding serum inflammatory markers compared. Flow cytometry was used to detect the number of CD4+ T cells and CD4+ T/CD8+ T value. Results AIDS patients received HAART treatment group before and after treatment for 6 months,12 months, and normal venous hs-CRP,TNF-α,Ang-Ⅱ levels respectively were 7.37±1.55ml/L,0.75±0.24ng/L,97.2±7.6pg/L,4.65±1.48ml/L,0.48±0.20ng/L,90.0±8.2pg/L,3.82±1.45ml/L,0.40±0.16ng/L,87.2±7.4pg/L and 2.68±1.08ml/L,0.32±0.16ng/L,64.2±10.5pg/L;and compared with before treatment, treatment for 6 months and 12 months after the hs-CRP,TNF-α, Ang-Ⅱ levels were significantly lower (P<0.05); the number of CD4+ T cells and CD4+ T/CD8+ T value increased. Conclusion Highly active antiretroviral therapy can reduce the levels of serum hs-CRP,TNF-α, Ang-Ⅱ and other inflammatory markers in AIDS patients, improve the immune system function and control the development of AIDS. |
| keywords:AIDS|Highly active antiretroviral therapy|High sensitive C-reactive protein|Tumor necrosis factor|Angiotensin Ⅱ |
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