| 血清半乳糖凝集素-3用于2型糖尿病相关肾病的诊断价值研究 |
| 投稿时间：2016-01-18 修订日期：2016-01-22 点此下载全文 |
| 引用本文：张利红,王亚妮,梅春丽.血清半乳糖凝集素-3用于2型糖尿病相关肾病的诊断价值研究[J].医学研究杂志,2016,45(8):119-124 |
| DOI：
10.11969/j.issn.1673-548X.2016.08.032 |
| 摘要点击次数: 798 |
| 全文下载次数: 836 |
|
| 基金项目:中国人民解放军第323医院内分泌科临床研究基金资助项目（2012323B10） |
|
| 中文摘要:目的 探讨血清半乳糖凝集素-3（galectin-3）用于2型糖尿病（type 2 diabetes mellitus，T2DM）患者发生糖尿病相关肾病（diabetic kidney disease，DKD）的诊断价值。方法 回顾性纳入2009年4月～2015年5月在笔者医院内分泌科及肾内科住院的T2DM患者130 例，根据尿白蛋白及接受透析情况分为尿白蛋白正常至中度增加（A1期）组（n=49）、中度增加（A2期）组（n=36）、重度增加（A3期）组（n=28）及透析组（n=17）。就诊时纪录患者一般情况及常规实验室检测指标。检测患者血清galectin-3及胱抑素C（Csy-C）水平，分析galectin-3与临床指标的相关性。使用ROC曲线分析galectin-3单独及联合Csy-C用于诊断DKD肾功能损害的价值。结果 透析组血清galectin-3水平（87.47±26.65ng/ml）最高，随后依次为A3期、A2期、A1期及健康对照组；eGFR≤15ml/（min·1.73m2）或透析患者galectin-3水平也显著高于其他eGFR情况的患者。所有患者中，galectin-3与尿白蛋白肌酐比（ACR）（r=0.760，P=0.000）及Csy-C（r=0.723，P=0.000）呈正相关，与eGFR（r=-0.768，P=0.000）呈负相关。Galectin-3单独诊断肾功能损害的AUC为0.908（95% CI：0.859～0.958），联合Csy-C的AUC为0.920（95% CI：0.873～0.967）。结论 T2DM患者血清galectin-3水平升高提示更严重的白蛋白尿及肾功损害，galectin-3单用或联合Csy-C具有良好的对肾功能损害的诊断价值。 |
| 中文关键词:2型糖尿病 糖尿病相关肾病 半乳糖凝集素-3 肾小球滤过率 诊断 |
| |
| Serum Galectin-3 Level in Diabetic Kidney Disease Patients with Type 2 Diabetes Mellitus and Its Clinical Diagnostic Value |
|
|
| Abstract:Objective To investigate the diagnostic value of serum Galectin-3 in diabetic kidney disease (DKD) patients with type 2 diabetes mellitus (T2DM). Methods A total of 130 patients with T2DM from April 2009 to May 2015 in endocrinology and nephrology department in our hospital were enrolled, and they were divided into normal to moderate increase (A1) group (n=49), moderate increase (A2) group (n=36) and severe increase (A3) group (n=28) and dialysis group (n=17) according to the urine albumin and dialysis situation. The general informations and the routine laboratory parameters were recorded. The serum Galectin-3 and cystatin C (Csy-C) levels were tested. ROC curve was used to analyze the clinical value of Galectin-3 alone and combined with Csy-C for diagnosis of renal function impairment in DKD. Results Serum Galectin-3 level in dialysis group (87.47±26.65ng/ml) was the highest, followed by A3, A2, A1 and control group. Galectin-3 level in patients with eGFR ≤15ml/(min·1.73m2) or dialysis was significantly higher than that in other patients. In all patients, Galectin-3 was positively correlated with urinary albumin to creatinine ratio (ACR) (r=0.760, P=0.000) and Csy-C (r=0.723, P=0.000), and negatively correlated with eGFR (r=-0.768, P=0.000) respectively. AUC of Galectin-3 for diagnosis of renal function damage alone was 0.908 (95% CI: 0.859-0.958), the AUC of Galectin-3 combined with Csy-C was 0.920 (95% CI: 0.873-0.967). Conclusion The elevation of serum Galectin-3 level in patients with T2DM indicates the severe urinary and renal dysfunction, and there is a good value of Galectin-3 alone or combined with Csy-C for diagnosis of renal dysfunction. |
| keywords:Type 2 diabetes mellitus Diabetic kidney disease Galectin-3 Glomerular filtration rate Diagnosis |
| 查看全文 查看/发表评论 下载PDF阅读器 |
