| 浙江省西南部地区儿童血清25-(OH)D水平研究 |
| 投稿时间：2015-12-07 修订日期：2015-12-28 点此下载全文 |
| 引用本文：李慧竹,雷后兴,王华富,郑桂爱,兰秀聪,樊慧苏,吴静,陈佳琦.浙江省西南部地区儿童血清25-(OH)D水平研究[J].医学研究杂志,2016,45(9):106-110 |
| DOI：
10.11969/j.issn.1673-548X.2016.09.028 |
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| 基金项目:丽水市市级公益性技术应用研究项目（2013ZC011）；丽水市市级公益性技术应用研究项目（2013JYZB40） |
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| 中文摘要:目的 了解浙江省西南部（以下简称浙西南）青少年儿童维生素D营养状态，为浙西南儿童合理补充维生素D提供科学依据。方法 2014年来笔者医院儿童生长发育专科进行25-（OH）D检测的3382例0~15岁健康儿童，均采用电化学发光法检测血清25-羟维生素D[25-（OH）D]水平。结果 在2620例4~15岁儿童中，25-（OH）D缺乏517例（19.73%），亚临床缺乏1113例（42.48%），适宜水平990例（37.79%）；在762例0~3岁婴幼儿中，25-（OH）D缺乏30例（3.94%）和亚临床缺乏者92例（12.07%），适宜水平640例（83.99%）；两组血清25-（OH）D比较，4~15岁儿童组（28.04±9.37μg/L）明显低于0~3岁婴幼儿组（42.23±12.91μg/L），差异有统计学意义（P<0.01）。2620例4~15岁儿童，中男童1444例，女童1176例，血清25-（OH）D水平分别为28.26±9.23和27.77±9.53μg/L，差异无统计学意义（P>0.05）。1年12个月中，2620例4~15岁儿童冬春季组1193例，夏秋季组1427例，血清25-（OH）D水平分别为26.45±9.83和29.38±8.74μg/L，差异有统计学意义（P<0.01）。夏秋季组和冬春季组按不同年龄段分组，组间对比差异均有统计学意义（P<0.01），以4~6岁夏秋季组最高（32.32±9.17μg/L），13~15岁冬春季组最低（21.37±8.31μg/L）。结论 浙西南4~15岁儿童除夏秋季学龄前组外，维生素D均缺乏；且年龄越大，血清25-（OH）D水平越低，以初中组最低；与性别无关。浙西南儿童应重视额外的维生素D摄入，尤需重视7岁以上儿童维生素D的补充。 |
| 中文关键词:维生素D 血清25-羟维生素D 营养状态 浙西南儿童 |
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| Study on Serum 25-(OH)D Level in Children in the Southwest of Zhejiang Province |
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| Abstract:Objective To understand the nutritional status of vitamin D in the children of the southwest of Zhejiang Province, and provide scientific basis for the reasonable supplement of vitamin D in the southwest of Zhejiang Province. Methods The serum levels of 25-hydroxy vitamin D [25-(OH) D] were detected by Electrochemical luminescence method in 3382 cases children aged 0 to 15 in our hospital specialist children's growth in 2014. Results (1) Of 2620 cases children aged 4~15, 517 cases (19.73%) were lack of 25-(OH)D, 1113 cases(42.48%) had subclinical lack, and 990 cases (37.79%) had appropriate levels. In 762 infants and young children aged 0 to 3 included 25-(OH)D deficiency of 30 (3.94%) and subclinical lack of 92 (12.07%), and the appropriate level of 640 (83.99%). In the two groups, serum 25-(OH)D of 4-15 years old children series was 28.04±9.37μg/L, significantly lower than that in the 0-3 years old infants and young children 42.23±12.91μg/L, and the difference was statistically significant (P<0.01). Of 2620 cases children aged 4-15, 1444 cases were boys and 1176 cases were girls. Serum 25-(OH)D levels were 28.26±9.23μg/L and 27.77±9.53μg/L respectively, which had no statistically significant difference (P>0.05). In a year, of 2620 cases children aged 4-15, 1193 cases were in winter spring group, 1427 cases were in summer fall group and their serum 25-(OH)D levels were 26.45±9.83μg/L and 29.38±8.74μg/L respectively, with significant difference (P<0.01). Summer fall and winter spring group according to different age groups had significant differences (P<0.01), with 4-6 years old Summer fall group was the highest 32.32±9.17μg/L, and 13-15 years old winter spring group was minimum 21.37±8.31μg/L. Conclusion Vitamin D was deficient in children aged 4~15 in the southwest of Zhejiang Province except the summer fall preschool groups. The mean serum 25-(OH) D levels were reduced along with age, which was lowest in the junior high school group and had no correlation with sex. Extra vitamin D intake of children in the southwest of Zhejiang Province should be paid attention to, especially in children over 7-year-old. |
| keywords:Vitamin D 25-(OH)D Nutritional status Children in the southwest of Zhejiang province |
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