| 血清糖皮质激素受体在难治性肺炎支原体肺炎患儿中的变化及临床意义 |
| 投稿时间：2016-03-07 修订日期：2016-03-23 点此下载全文 |
| 引用本文：姚欢银,张佩红,童海明,刘伟荣,刘淑梅,陈啸洪.血清糖皮质激素受体在难治性肺炎支原体肺炎患儿中的变化及临床意义[J].医学研究杂志,2016,45(10):82-84 |
| DOI：
10.11969/j.issn.1673-548X.2016.10.021 |
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| 基金项目:浙江省医药卫生一般研究计划项目（2015KYA219） |
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| 中文摘要:目的 通过检测难治性肺炎支原体肺炎（RMPP）患儿血清GRα及GRβ蛋白表达水平的变化，为临床合理应用糖皮质激素（GC）提供理论依据。方法 2014年1月~2015年5月在笔者医院儿内科住院的226例年龄在3~12岁肺炎患儿，按临床症状和实验室检查分为肺炎组和肺炎支原体肺炎（MPP）组，采用ELISA法检测血清GRα及GRβ蛋白表达水平；同时对MPP组按照诊断标准分为普通MPP组和RMPP组，观察两组血清GRα及GRβ水平变化。结果 MPP组血清GRα水平（19.73±5.05ng/ml）明显高于肺炎组（11.76±3.46ng/ml）和对照组（9.41±3.31ng/ml）（P<0.01），后两组比较差异有统计学意义（P<0.01）；GRβ水平在MPP组（9.40±2.37ng/ml）和肺炎组（9.67±2.13ng/ml）则明显高于对照组（7.71±1.98ng/ml）（P<0.01），而前两组比较差异无统计学意义（P>0.05）；MPP组GRα/GRβ比值（2.29±0.94）明显高于肺炎组（1.31±0.57）和对照组（1.36±0.73）（P<0.01），而后两组之间比较差异无统计学意义（P>0.05）；RMPP患儿中血清GRα水平和GRα/GRβ比值显著高于普通MPP组（24.49±3.16ng/ml vs 16.49±3.17ng/ml，P<0.01；9.58±2.49 vs 2.90±0.99，P<0.01），GRβ水平（9.13±3.19ng/ml vs 9.58±2.49ng/ml，P>0.05）两组差异无统计学意义。结论 在MPP和RMPP中存在着GRα的优势表达，GRα/GRβ比值增大，尤其在RMPP中表现更为明显。 |
| 中文关键词:难治性肺炎支原体肺炎 糖皮质激素受体 儿童 |
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| Clinical Significance of Changes of Serum Glucocorticoid Receptor in Children with Refractory Mycoplasma Pneumoniae Pneumonia |
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| Abstract:Objective To investigate the changes of glucocorticoid receptor including glucocorticoid receptor-α(GRα) and glucocorticoid receptor-β(GRβ) in peripheral blood in patients with refractory mycoplasma pneumoniae pneumonia(RMPP), to provide a theoretical basis of the glucocorticoid(GC) therapy. Methods There were 226 children with pneumonia admitted from January 2014 to May 2015 in our hospital. According to clinical symptoms and laboratory examination, they were divided into pneumonia group and mycoplasma pneumoniae pneumonia (MPP) group. Serum GRαand GRβ protein expression levels were measured by ELISA. The MPP group according to the diagnosis standard was divided into ordinary MPP group and the RMPP group. Serum GRα and GRβ level changes of two groups were observe. Results The serum levels of GRα level in MPP group(19.73±5.05ng/ml) were significantly higher than those of ordinary pneumonia group(11.76±3.46ng/ml)and control group(9.41±3.31ng/ml)(P<0.01). Comparison between the latter two groups had significantly difference(P<0.01). The levels of GRβ in MPP group(9.40±2.37ng/ml)and pneumonia group(9.67±2.13ng/ml) were significantly higher than those of the control group(7.71±1.98ng/ml) (P<0.01), but there was no significantly difference between the former two groups(P>0.05). GRα/GRβ ratio in MPP group(2.29±0.94)was significantly higher than that of ordinary pneumonia group(1.31±0.57)and the control group(1.36±0.73)(P<0.01), but the latter two groups had no significantly difference(P>0.05). The levels of serum GRα and GRα/GRβ ratio in RMPP group were significantly higher than those in ordinary MPP group(24.49±3.16ng/ml vs 16.49±3.17ng/ml, P<0.01;9.58±2.49 vs 2.90±0.99, P<0.01), and there was no significant difference between the two groups of GRβ(9.13±3.19ng/ml vs 9.58±2.49ng/ml, P>0.05). Conclusion There was the advantage of GRα expression in MPP and RMPP. The ratio of GRα/GRβ was significantly increased, especially in RMPP. |
| keywords:Refractory mycoplasma pneumoniae Glucocorticoid receptor Children |
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