| 血、尿中性粒细胞明胶酶相关载脂蛋白在慢性肾脏病3期中的变化及意义 |
| 投稿时间：2016-03-17 修订日期：2016-04-01 点此下载全文 |
| 引用本文：倪佳宁,蔡旭东,魏升,邢洁,伍云洲.血、尿中性粒细胞明胶酶相关载脂蛋白在慢性肾脏病3期中的变化及意义[J].医学研究杂志,2016,45(10):89-91,94 |
| DOI：
10.11969/j.issn.1673-548X.2016.10.023 |
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| 基金项目:宁波市自然科学基金资助项目（2014A610207） |
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| 中文摘要:目的 探讨血、尿中性粒细胞明胶酶相关载脂蛋白（neutrophil gelatinase associated lipocalin，NGAL）在慢性肾脏病（chronic kidney disease，CKD）3期患者中的变化及意义。方法 选择CKD3期患者80例，采用ELISA法测定随访者的血、尿NGAL水平，同时检测患者尿蛋白、尿N-乙酰-β-D-葡萄糖苷酶（NAG）、肾小球滤过率（GFR）、血清白蛋白等指标，并与30例体检健康者作比较，分析血清和尿液中NGAL的变化以及与其他肾脏指标的相关性。结果 CKD3期组血、尿NGAL与健康对照组相比，差异均有统计学意义（P<0.05）；CKD3期患者血清NGAL与GFR呈负相关，线性方程为y=-0.204x+26.869，r=-0.204，P<0.05；尿液NGAL与GFR亦呈负相关，线性方程为y=-0.072x+7.615，r=-0.072，P<0.05。CKD3期患者血清NGAL与血清白蛋白呈负相关，线性方程为y=-0.071x+8.065，r=-0.071，P<0.05。此外，CKD3期患者中2型糖尿病肾病患者的尿NGAL与其尿总蛋白/尿肌酐呈正相关，线性方程为y=0.005x-0.783，r=0.005，P<0.05；痛风性肾病患者的尿NGAL与尿NAG呈正相关，线性方程为y=0.426x-11.32，r=0.426，P<0.05。结论 血、尿NGAL能够有效评价慢性肾脏病的肾损伤程度及其进展预后。 |
| 中文关键词:中性粒细胞明胶酶相关载脂蛋白 慢性肾脏病3期 2型糖尿病肾病 痛风性肾病 |
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| Expression and Significance of Serum and Urine NGAL in Chronic Kidney Disease 3 Period |
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| Abstract:Objective To explore the expression and significance of serum and urine neutrophil gelatinase associated lipocalin (NGAL) in chronic kidney disease (CKD) 3 period. Methods Eighty cases of patients with CKD 3 period were selected and 30 healthy subjects were as control. NGAL in serum and urine was detected by ELISA. The level of urinary protein, urinary N-acetyl-β-D-grape glycosides (NAG), glomerular filtration rate (GFR), and serum albumin was also detected. Change in serum NGAL and urine NGAL between two groups was observed, and relevance with other kidney indicators was analyzed. Results Serum NGAL and urine NGAL in CKD 3 period both were higher than those in healthy group, and the difference was significant(P<0.05). In CKD 3 period group, level of serum NGAL was negatively correlated with GFR (linear equation: y=-0.204x+26.869, r=-0.204, P<0.05), level of urinary NGAL was also negatively correlated with GFR(linear equation: y=-0.072x+7.615, r=-0.072, P<0.05). Besides, in CKD 3 period patients with type 2 diabetic nephropathy, level of urinary NGAL was positively correlated with urinary protein/creatinine ratio (linear equation: y=0.005x-0.783, r=0.005, P<0.05). While in CKD 3 period patients with gout nephropathy, level of urinary NGAL was positively correlated with urinary NAG(linear equation: y=0.426x-11.32, r=0.426, P<0.05). Conclusion Serum NGAL and urinary NGAL could be used to effectively evaluate chronic kidney injury and progress. |
| keywords:Neutrophil gelatinase-associated lipocalin Chronic kidney disease 3 period Type 2 diabetic nephropathy Gout nephropathy |
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