131I和甲巯咪唑对Graves病患者外周血Treg细胞及IL-10水平的影响
投稿时间:2016-03-10  修订日期:2016-03-23  点此下载全文
引用本文:胡希红,魏广玉,倪红.131I和甲巯咪唑对Graves病患者外周血Treg细胞及IL-10水平的影响[J].医学研究杂志,2016,45(10):114-116,127
DOI: 10.11969/j.issn.1673-548X.2016.10.030
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作者单位
胡希红 116001 大连市友谊医院老年病科 
魏广玉 116001 大连市友谊医院老年病科 
倪红 116011 大连市老年病医院老年病科 
中文摘要:目的 观察131I和甲巯咪唑治疗Graves病(GD)前后调节性T细胞(Treg)和白细胞介素-10(IL-10)的变化,并探讨其相关的临床意义。方法 选取2013年4月~2015年11月笔者医院收治的GD患者88例,随机分为131I治疗组和甲巯咪唑治疗组,每组44例。选择同期笔者医院健康体检者40例作为正常对照。血清IL-10的检测使用ELISA法,流式细胞仪检测Treg细胞。比较两组治疗前后FT3、FT4和TSH。结果 GD患者Treg细胞比例为3.25%±0.84%,显著低于正常对照组的7.14%±2.13%(P<0.01),GD患者IL-10因子表达为8.22±1.73μmol/L,也显著低于正常对照组的15.64±3.17μmol/L(P<0.01)。131I和甲巯咪唑组治疗前GD患者Treg细胞比例和IL-10因子表达差异无统计学意义(P>0.05),治疗后131I组Treg细胞比例和IL-10因子表达出现显著升高(P<0.05),但甲巯咪唑组上述指标治疗前后无显著性差异(P>0.05)。131I和甲巯咪唑组治疗前GD患者FT3、FT4和TSH差异无统计学意义(P>0.05),治疗后两组FT3和FT4均显著减低(P<0.01),TSH均显著升高(P<0.05)。但131I组对FT3和FT4的减低作用以及对TSH的升高作用显著优于甲巯咪唑组(P<0.05)。结论 131I可提高Graves病患者Treg细胞比例和IL-10因子表达,临床疗效显著。
中文关键词:Graves病  131I  甲巯咪唑  调节性T细胞(Treg)  白介素-10
 
Effect of 131I and Methimazole on Treg Cells and IL-10 in Graves Disease
Abstract:Objective To detect the effect of 131I and methimazole on Treg cells and IL-10 in Graves disease(GD) and explore its related clinical significance. Methods A total of 88 GD patients were enrolled in this study. Patients were randomly divided into: 131I group(n=44) and methimazole group(n=44). Another 40 health person serred as normal control. Serum IL-10 was detected by ELISA method. Flow cytometry was used to detect Treg cells. FT3, FT4 and TSH was compared between the two groups before and after treatment. Results The proportion of Treg cells in GD patients was 3.25%±0.84%, which was significantly lower than that of 7.14%±2.13% in normal control group (P<0.01) and IL-10 expression in GD patients was 8.22±1.73μmol/L, which was significantly lower than that of 15.64±3.17μmol/L in normal control group (P<0.01). After treatment, Treg cells and IL-10 expression were significantly increased in 131I group (P<0.05), but which was not changed in methimazole group (P>0.05). After treatment, the effect of reducing FT3, FT4 and increasing of TSH in 131I group was significantly higher than that of methimazole group (P<0.05). Conclusion 131I can increase Treg cells and IL-10 expression in GD patients, with significantly clinical effect.
keywords:Graves disease(GD)  131I  Methimazole  Treg cells  IL-10
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