| 血清HE4、CA125、VEGF联合检测对卵巢癌诊断价值分析 |
| 投稿时间：2016-02-14 修订日期：2016-03-20 点此下载全文 |
| 引用本文：牛艳昕,王楠,刘杰.血清HE4、CA125、VEGF联合检测对卵巢癌诊断价值分析[J].医学研究杂志,2016,45(10):142-144,56 |
| DOI：
10.11969/j.issn.1673-548X.2016.10.037 |
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| 中文摘要:目的 探讨血清人附睾蛋白4（HE4）、癌抗原-125（CA125）、血管表皮生长因子（VEGF）联合检测对卵巢癌诊断价值，为临床诊断提供一定的参考价值。方法 本研究病例来源于2013年5月~2015年5月期间笔者医院收治的107例卵巢疾病患者，按照术后病理结果将其分为卵巢癌组43例与良性病变组64例。选择同期于笔者医院体检中心体检的健康女性50例作为健康对照组。检测各组血清HE4、CA125、VEGF水平变化及联合检测敏感度和特异性。结果 卵巢癌组和卵巢良性病变组血清HE4水平明显高于健康对照组（P<0.05）；卵巢癌组血清HE4水平明显高于卵巢良性病变组（P<0.05）；卵巢癌组和卵巢良性病变组血清CA125水平明显高于健康对照组（P<0.05）；卵巢癌组血清CA125水平明显高于卵巢良性病变组（P<0.05）；卵巢癌组和卵巢良性病变组血清VEGF水平明显高于健康对照组（P<0.05）；卵巢癌组血清VEGF水平明显高于卵巢良性病变组（P<0.05）；血清HE4+CA125+VEGF联合检测敏感度和特异性明显高于单检测血清HE4、CA125、VEGF（P<0.05）。结论 血清HE4、CA125、VEGF在卵巢癌患者中呈高表达，3种肿瘤标志物联合检测具有着较高的敏感度和特异性，可作为诊断卵巢癌的重要手段，具有重要研究价值。 |
| 中文关键词:人附睾蛋白4 癌抗原-125 血管表皮生长因子 |
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| Diagnostic Value of Combined Detection of Serum HE4, CA125 and VEGF in the Diagnosis of Ovarian Cancer |
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| Abstract:Objective To investigate the value of serum human epididymis protein 4 (HE4), cancer antigen -125 (CA125) and vascular epidermal growth factor (VEGF) in the diagnosis of ovarian cancer, and provide some reference value for clinical diagnosis. Methods A total of 107 cases of ovarian disease in our hospital from May 2013 to May 2015 were studied. According to the postoperative pathological results, it was divided into 43 cases of ovarian cancer group and 64 cases of benign lesion group. We selected 50 cases of the healthy women the same period in physical examination center of our hospital at as a healthy control group. Serum levels of HE4, CA125, VEGF, and the combined sensitivity and specificity were detected. Results The level of serum HE4 in ovarian cancer group and benign ovarian disease group was significantly higher than that in healthy control group (P<0.05), and the serum HE4 level was significantly higher than that in patients with benign ovarian disease (P<0.05). The level of serum CA125 in ovarian cancer group and benign ovarian disease group was significantly higher than that in healthy control group (P<0.05), and the serum CA125 level was significantly higher than that in the patients with benign ovarian disease (P<0.05). The level of serum VEGF in ovarian cancer group was significantly higher than that in ovarian benign disease group (P<0.05). The sensitivity and specificity of combined detection of serum HE4+CA125+VEGF were significantly higher than that of single detection of serum HE4, CA125, VEGF sensitivity and specificity (P<0.05). Conclusion Serum HE4, CA125 and VEGF in ovarian cancer patients showed higher expression. Combined detection of three tumor markers had high sensitivity and specificity.It can be used as an important means of the diagnosis of ovarian cancer, and has the important research value. |
| keywords:Human epididymis protein 4 Cancer antigen -125 Vascular epidermal growth factor |
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