| 急性心肌梗死患者血清尿酸水平与心功能变化的相关性研究 |
| 投稿时间：2016-04-28 修订日期：2016-04-28 点此下载全文 |
| 引用本文：黄红丽,李卫萍.急性心肌梗死患者血清尿酸水平与心功能变化的相关性研究[J].医学研究杂志,2016,45(11):58-60,65 |
| DOI：
10.11969/j.issn.1673-548X.2016.11.015 |
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| 基金项目:国家自然科学基金资助项目（81300161）；北京市卫生系统高层次卫生技术人才基金资助项目（2013-3-060） |
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| 中文摘要:目的 探讨急性心肌梗死（AMI）患者血清尿酸（UA）水平与心功能评价指标的相关性。方法 入选2015年1~12月入院的AMI患者157例，根据血清UA水平分为高尿酸血症组（n=41）和尿酸正常组（n=116）。比较两组患者一般资料、血液检测指标、超声心动图各指标及Grace危险评分，并分析UA与各指标的相关性。结果 高尿酸血症组体重指数（BMI）、合并高血压病比例、甘油三酯（TG）、N末端脑钠肽前体（NT-proBNP）、Grace评分以及左心室收缩末期容积（LVESV）较尿酸正常组高（P<0.05或P<0.01），而左心室射血分数（LVEF）及左心室短轴缩短分数（FS）显著降低（P<0.05）。单因素相关分析结果显示，高尿酸组尿酸水平与年龄、LDL-C、NT-ProBNP、Grace评分、LVESV和左心室舒张末期容积（LVEDV）呈正相关（P<0.05），与LVEF呈负相关（P<0.05）。结论 AMI合并高尿酸血症患者左心室收缩功能受损更明显，院内死亡风险更高，提示预后更差。 |
| 中文关键词:尿酸 急性心肌梗死 心功能 |
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| Study of the Relationship Between Serum Uric Acid Level and Cardiac Function in Acute Myocardial Infarction Patients |
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| Abstract:Objective To investigate the relationship between serum uric acid(UA) concentration and cardiac function in patients with acute myocardial infarction(AMI). Methods A total of 157 AMI patients in Beijing friendship hospital from January 2015 to December 2015 were enrolled and were divided into high UA group(n=41) and normal UA group(n=116).Clinical features,blood tests, echocardiogram and Grace risk scores were compared between the two groups. Results The body mass index, proportion of hypertension, triglyceride, N-terminal B-type natriuretic peptide (NT-proBNP), GRACE risk score and left ventricular end systolic volume(LVESV) were significantly higher in high UA group than normal UA group (P<0.05 or P<0.05) and left ventricular ejection fraction (LVEF) and left ventricular fractional shortening(FS) were significantly lower(P<0.05). Morever, serum UA concentration in the high UA group was positively related with age, low density lipoprotein-cholesterol(LDL-C), NT-proBNP,GRACE risk score, left ventricular end diastolic volume(LEVDV) and LVESV (P<0.05),and was negatively related with LVEF and FS(P<0.05). Conclusion AMI patients with high level of UA have more serious impairment of left ventricular systolic function, higher risk of in-hospital death and poor prognosis. |
| keywords:Uric acid Acute myocardial infarction Cardiac function |
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