| ALT≤2×ULN的CHB患者明显肝脏炎症血清生化学替代诊断标志物研究 |
| 投稿时间：2015-12-16 修订日期：2016-01-07 点此下载全文 |
| 引用本文：卓其斌,李强,陈冲,李微霞,陈良.ALT≤2×ULN的CHB患者明显肝脏炎症血清生化学替代诊断标志物研究[J].医学研究杂志,2016,45(11):100-103 |
| DOI：
10.11969/j.issn.1673-548X.2016.11.025 |
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| 基金项目:上海市科委“科技创新行动计划”医学与农业领域重点项目（13401902100） |
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| 中文摘要:目的 探讨血清转氨酶水平正常或轻度升高的慢性乙型肝炎（chronic hepatitis B，CHB）患者肝脏炎症的血清生化学替代标志物。方法 回顾性纳入100例血清谷丙转氨酶（alanine transaminase，ALT）水平正常或轻度升高（<2倍正常值上限）的CHB患者。明显肝脏炎症定义为炎症分级≥G2。比较无明显肝脏炎症组与明显肝脏炎症组间临床及生化学指标。结果 100例患者中，无明显肝脏炎症组56例，占56%；明显肝脏炎症组44例，占44%。单因素回归分析显示ALT、AST、碱性磷酸酶、谷氨酰转肽酶、白蛋白、球蛋白、凝血酶原时间、血小板和中性粒细胞绝对数与明显肝脏炎症相关（P均<0.05）。多因素回归分析显示GGT是明显肝脏炎症的独立预测因素（P<0.05）。结论 血清GGT是转氨酶水平正常或轻度升高的CHB患者明显肝脏炎症的独立预测因素，可以用做ALT≤2×ULN的CHB患者明显肝脏炎症的诊断标志物。 |
| 中文关键词:慢性乙型肝炎 谷氨酰转肽酶 血清生化学标志物 明显肝脏炎症 |
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| Investigation of Serum Biochemical Alternative Markers Which Can Effectively Predict Significant Liver Inflammation in CHB Patients with ALT≤2×ULN |
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| Abstract:Objective To investigate the simple serum markers that can effectively predict significant liver inflammation in chronic hepatitis B (CHB) patients with normal or within 2 times elevated alanine aminotransferase (ALT) levels. Methods One hundred CHB patients with normal or within 2 times elevated ALT levels (<80IU/L) were retrospectively enrolled. Significant liver inflammation was defined as a liver inflammatory activity grade ≥G2. The difference of various clinical markers between CHB patients with and without significant liver inflammation was compared. Results Of 100 CHB patients, 56 patients (56%) had non-significant liver inflammation and 44 patients (44%) had significant liver inflammation. By univariate regression analysis, the ALT, AST, alkaline phosphatase (ALP), gamma-glutamyl transpeptidase (GGT), albumin, globulin, prothrombin time (PT), prothrombin time (PT), and absolute neutrophil count (ANC).By multivariate regression analysis, the gamma-glutamyl transpeptidase (GGT) was identified as the only independent predictor of significant liver inflammation. Conclusion The GGT was independent predictor of significant liver inflammation in CHB patients with normal or within 2 times elevated ALT levels, which could be used to predict significant liver inflammation in this patients group. |
| keywords:Chronic hepatitis B GGT Serum biochemical markers Significant inflammation |
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