| 治疗前中性粒细胞淋巴细胞比值对下肢ASO患者死亡的预测作用 |
| 投稿时间：2016-03-18 修订日期：2016-04-15 点此下载全文 |
| 引用本文：王躲发,刘斌,秦乾洪,纪明月,朱化刚.治疗前中性粒细胞淋巴细胞比值对下肢ASO患者死亡的预测作用[J].医学研究杂志,2016,45(11):118-120 |
| DOI：
10.11969/j.issn.1673-548X.2016.11.030 |
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| 中文摘要:目的 探讨治疗前中性粒细胞淋巴细胞比值（NLR）对下肢动脉硬化闭塞症（ASO）患者死亡的影响。方法 收集安徽医科大学第一附属医院2011年1月~2015年6月下肢ASO患者的临床资料，根据治疗前NLR值将患者分为高NLR组（NLR≥5.7）与低NLR组（NLR<5.7），利用K-M曲线比较两组患者的生存率，利用COX多因素模型比较各临床资料对患者生存率的影响，利用ROC曲线评估NLR分界值对患者死亡预测的敏感度和特异性。结果 低NLR组患者生存率较高NLR组患者生存率高，差异有统计学意义（81.4% vs 42.4%，P<0.05）。NLR≥5.7是影响本研究组患者死亡的独立危险因素。NLR取值为5.7时敏感度为60.7%，特异性为79.3%。结论 治疗前NLR对下肢ASO患者死亡具有一定的预测作用。 |
| 中文关键词:动脉硬化 闭塞性 中性粒细胞/淋巴细胞比值 预后 |
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| Effect of Pre-treatment Neutrophil-lymphocyte Ratio on the Mortality of Patients with Lower Limbs Arteriosclerosis Obliterans |
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| Abstract:Objective To analyze the association of pre-treatment neutrophil-lymphocyte ratio(NLR)and mortality of patients with lower limbs arteriosclerosis obliterans(ASO). Methods The patients with ASO from the first affiliate hospital of Anhui Medical University between January 2011 to June 2015 were divided into two groups, according to the value of NLR,Kaplan-Meier method were used to compare the survival of two groups.COX regression analysis was conducted to analyze the effect of clinical factors on the mortality and ROC curve was conducted to calculate the sensitivity and specificity. Results The survival rate of lower NLR group was significantly higher than higher NLR group(81.4% vs 42.4%,P<0.05).NLR≥5.7 was an independent risk factor of the mortality of ASO patients. The sensitivity was 60.7% and specificity was 79.3% when NLR was 5.7. Conclusion Pre-treatment NLR is an effective indicator predicting the mortality of ASO. |
| keywords:Atherosclerosis Occlusive Neutrophil-lymphocyte ratio Prognosis |
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