| 神经元特异性烯醇化酶在不同病因所致脑损伤中的鉴别诊断价值 |
| 投稿时间：2015-04-09 修订日期：2016-04-14 点此下载全文 |
| 引用本文：王飞,徐凌,姜婷婷,游达礼,吴晓,王莉,居学丰,胡善友.神经元特异性烯醇化酶在不同病因所致脑损伤中的鉴别诊断价值[J].医学研究杂志,2016,45(11):141-144,53 |
| DOI：
10.11969/j.issn.1673-548X.2016.11.036 |
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| 基金项目:上海市嘉定区卫生系统第三批重点学科建设项目基金资助项目（ZD01）；上海市嘉定区中心医院第十一批中青年骨干培养计划项目基金资助项目 |
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| 中文摘要:目的 探讨血清神经元特异性烯醇化酶（NSE）水平在不同病因（脑梗死及呼吸衰竭）所致脑损伤的鉴别诊断价值。方法 连续选择2014年10月~2015年10月于上海市嘉定区中心医院急诊科就诊的脑梗死及呼吸衰竭患者，根据不同病因分为脑梗死组（n=63）和呼吸衰竭组（n=31），比较两组的一般资料及实验室指标（包括NSE）的差异。再根据意识状态分为昏迷组（n=19）和无昏迷组（n=75），比较NSE水平的差异，并对NSE与相关有意义的指标进行相关分析。结果 所有病例总体NSE异常率为26.6%，呼吸衰竭组的NSE水平显著高于脑梗死组[12.54（12.95）ng/ml vs 11.05（5.80）ng/ml，P=0.046]，而TBIL、ALB、PaO2显著降低（P均<0.05）；昏迷组的NSE水平显著高于无昏迷组[16.35（10.77）ng/ml vs 11.05（4.32）ng/ml，P=0.018]。Spearman相关分析显示NSE与GCS评分呈负相关（r=-0.246，P=0.019）。结论 NSE水平与意识障碍程度密切相关，NSE可能对不同病因所致的脑损伤有一定的鉴别诊断价值。 |
| 中文关键词:神经元特异性烯醇化酶 脑梗死 呼吸衰竭 鉴别诊断 诊断价值 |
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| Differential Diagnosis Value of Neuron-specific Enolase among Patients with Brain Injury Caused by Different Etiology |
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| Abstract:Objective To investigate the differential diagnosis value of serum neuron specific enolase (NSE) levels in patients with brain damage caused by different etiology (cerebral infarction and respiratory failure). Methods The patients, who received treatment in Emergency department of Jiading district center hospital, were enrolled in the study continuously from October 2014 to October 2015. They were divided into cerebral infarction group(n=63) and respiratory failure group(n=31) based on their etiology. And accoding to their consciousness, they were divided into coma group(n=19) and non-coma group(n=75). Differences in Physical data and Laboratory data, including NSE level, were compared between the two groups. The correlation between the significant factors and NSE were analyzed by Spearman correlation test. Results In all 94 patients, the overall incidence of NSE level abnormal was 26.6%. Compared with the cerebral infarction group, the NSE level was significantly increased in respiratory failure group[12.54(12.95)ng/ml vs 11.05(5.80)ng/ml,P=0.046], on the contrary, the level of TBIL, ALB and PaO2 were significantly decreased(all P<0.05). Meanwhile, the NSE level was significantly increased in coma group than that in non-coma group[16.35(10.77)ng/ml vs 11.05(4.32)ng/ml,P=0.018].NSE level was significantly negatively correlated with GCS score (r=-0.246,P=0.019) by Spearman correlation analysis. Conclusion NSE level correlates well with the severity of disturbance of consciousness.NSE has a potential differential diagnosis value in patients with brain damage caused by different etiology. |
| keywords:Neuron specific enolase Cerebral infarction Respiratory failure Differential diagnosis Diagnostic value |
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