| 高同型半胱氨酸血症对2型糖尿病患者骨钙素的影响 |
| 投稿时间：2016-03-22 修订日期：2016-04-21 点此下载全文 |
| 引用本文：董鹏,邓秀玲,王俊宏,徐静,刘超峰.高同型半胱氨酸血症对2型糖尿病患者骨钙素的影响[J].医学研究杂志,2016,45(11):149-152 |
| DOI：
10.11969/j.issn.1673-548X.2016.11.038 |
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| 中文摘要:目的 探讨高同型半胱氨酸血症对2型糖尿病患者血清骨钙素的影响。方法 2型糖尿病患者106例，按性别分为男性组、绝经后女性组，男性组及绝经后女性组按血同型半胱氨酸水平分为高同型半胱氨酸组及正常同型半胱氨酸组，组间进行生化及临床特征比较。结果 男性高同型半胱氨酸组血清骨钙素与正常同型半胱氨酸组比较差异无统计学意义（P>0.05）。绝经后女性高同型半胱氨酸组校正年龄因素影响后，骨钙素、甲状旁腺素、甘油三酯高于正常同型半胱氨酸组。相关分析显示绝经后女性血清骨钙素与同型半胱氨酸、25羟维生素D、PTH相关。多元逐步线性回归示血同型半胱氨酸为影响绝经后女性骨钙素的独立相关因素。结论 绝经后女性高同型半胱氨酸血症组，血清骨钙素高于正常同型半胱氨酸组，高同型半胱氨酸血症与绝经后女性患者的血清骨钙素呈正相关。 |
| 中文关键词:血同型半胱氨酸 骨钙素 2型糖尿病 |
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| Effect of Hyperhomocysteinemia on Osteocalcin of Type 2 Diabetes |
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| Abstract:Objective To explore the impact of hyperhomocysteinemia on serum osteocalcin of pateints with type 2 diabetes. Methods Totally 106 patients with type 2 daibetes were divided into 2 groups according to the gender. Male and post-menopause female gruops were divided into the hyperhomocysteinemia and normal homocysteine gruops, based on the homocysteine level. The characteristic of the clinic and biochemistry of the two groups were compared. Results After adjudgment of age, osteocalcin, parathyroid hormone, triglyceride of the post-menopausal women hyperhomocysteinemia groups were higher than the post-menopausal women normal homocysteine gruop. Correlation analysis indicated the serum osteocalcin of post-menopausal women was correlated with homocysteine, serum osteocalcin, 25 hydroxylated vitamin D, PTH. Multiple stepwise linear regression indicated plasma homocysteine was independent related influenceing factor of osteocalcin. Conclusion Serum osteocalcin of hyperhomocysteinemia groups of post-menopausal women was higher than normal homocysteine gruops; hyperhomocysteinemia was postively associated with serum osteocalcin of post-menopause women with type 2 diabetes. |
| keywords:Homocysteine Osteocalcin Type 2 diabetes |
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