| HER-2阴性LuminalB型乳腺癌的临床病理特征研究 |
| 投稿时间：2016-04-14 修订日期：2016-05-01 点此下载全文 |
| 引用本文：刘虔,孙圣荣.HER-2阴性LuminalB型乳腺癌的临床病理特征研究[J].医学研究杂志,2016,45(11):169-173 |
| DOI：
10.11969/j.issn.1673-548X.2016.11.043 |
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| 中文摘要:目的 探讨HER-2阴性LuminalB型乳腺癌3种亚型的临床病理特征的差别并与LuminalA型乳腺癌进行比较，探索能否将3种亚型中的一部分乳腺癌独立出来重新归为LuminalA型乳腺癌。方法 回顾性分析126例HER-2阴性LuminalB型乳腺癌患者，并将其分为3组：组1为PR<20%且Ki-67<14%，组2为Ki-67≥14%且PR≥20%，组3为PR<20%且Ki-67≥14%，分析各组间临床病理资料的差异，并分别与LuminalA型乳腺癌进行比较。结果 HER-2阴性LuminalB型乳腺癌的3个亚组中，肿块直径组1与组3比较差异有统计学意义（P=0.040），组1与组2、组2与组3间比较差异无统计学意义（P>0.05）；腋窝淋巴结转移组1与组2比较差异有统计学意义（P<0.05），组1与组3、组2与组3间差异无统计学意义（P>0.05）；3个亚组在组织学分级及绝经状态方面差异互无统计学意义（P>0.05）；发病年龄组1与组2、组1与组3差异有统计学意义（P<0.05），组2与组3差异无统计学意义（P>0.05）；组1与组2在组织类型方面差异有统计学意义（P<0.05），组1与组3、组2与组3在组织类型方面差异无统计学意义（P>0.05）；将LuminalA型乳腺癌与组1、组2、组3比较，LuminalA型乳腺癌与组1的临床病理特征差异无统计学意义，而与组2、组3差异有统计学意义。结论 LuminalB型中的HER-2阴性LuminalB型乳腺癌可分为3个亚组，它们在临床病理方面存在着一定的差异，且组1与LuminalA型乳腺癌临床病理特征差异无统计学意义，或许能将组1重新归为LuminalA型乳腺癌，但需进一步前瞻性研究来证实。 |
| 中文关键词:HER-2阴性LuminalB 乳腺癌 临床病理特征 |
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| Research on the Pathological and Clinical Features of HER-2-negative-Luminal-B Type Breast Cancer |
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| Abstract:Objective To explore the pathological and clinical features difference of patients with HER-2-negative-Luminal-B type breast cancer. Methods Totally 126 patients with HER-2-negative-Luminal-B type breast cancer patients were divided into 3 groups, and were analyzed retrospectively. In the first group, PR was lower than 20% and Ki-67 was lower than 14%. In the second group, PR was higher or equal to 20% and Ki-67 was higher than or equal to 14%. In the third group, PR was lower than 20% and Ki-67 was higher than or equal to 14%. We collected clinical and pathology data, and analyzed difference of HER-negative-Luminal-B type breast cancer, and then compared with Luminal-A Type. Results Among the three subtypes of HER-2-negative-Luminal-B type breast cancer, the difference of tumer size brtween group 1 and group 3 was significant, the other was not significant. Compared with group 2, the group 1 was statistically significant of lymphatic metastasis(P<0.05), the diffrence of group 1 with group 3 and guoup 2 with group 3 was not significant(P>0.05), the pathological grade was not statistically significant among the 3 groups(P>0.05), the difference of menopause among three groups was not significant(P>0.05). Compared with group 2, the group 1 was statistically significant of pathological pattern(P<0.05), the difference among group1 with group 2 ang group 2 with group3 was not significant(P>0.05), the difference of age between group 1 and group 2, while between group 1 ang group 3 was statistically significant(P<0.05), among group 2 with group 3 was not significant(P>0.05). The difference of pathological and clinical features between Luminal-A type breast cancer an group 1 were not significant, but comapred with group 2 and group 3, the Luminal-A type breast cancer was statistically significant of pathological and clinical features. Conclusion According to PR and Ki-67, current HER-2-negative-Luminal-B type breast cancer can be divided into three different subtypes, which has different pathological and clinical features and the difference of pathological and clinical features between Luminal-A type breast cancer an group 1 were not significant that may redefined the group 1 as Luminal-A type breast cancer,but needs further study to demonstrate it. |
| keywords:HER-2-negative-Luminal-B type Breast cancer Pathological and clinical features |
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