整合素αvβ6和CD44v6在胃癌中的表达意义
投稿时间:2016-04-15  修订日期:2016-05-17  点此下载全文
引用本文:郭运生,赵敏,肖芳,周颖,黄江梅,张辉.整合素αvβ6和CD44v6在胃癌中的表达意义[J].医学研究杂志,2016,45(12):70-72
DOI: 10.11969/j.issn.1673-548X.2016.12.019
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作者单位E-mail
郭运生 066000 秦皇岛市第一医院普外科  
赵敏 066000 秦皇岛市第一医院病理科 496437510@qq.com 
肖芳 066000 秦皇岛市第一医院病理科  
周颖 066000 秦皇岛市第一医院病理科  
黄江梅 066000 秦皇岛市第一医院病理科  
张辉 066000 秦皇岛市第一医院病理科  
基金项目:秦皇岛市科技支撑项目(201501B045)
中文摘要:目的 观察整合素αvβ6和CD44v6在胃癌中的表达变化,探讨其临床病理意义。方法 采用免疫组织化学EnVision法分别检测72例胃癌组织、20例癌旁正常胃黏膜组织中整合素αvβ6和CD44v6的表达情况,分析二者在胃癌患者分化程度,淋巴结转移方面的相关性。结果 胃癌组αvβ6的阳性表达率63.8%显著高于癌旁正常胃黏膜组13%,有淋巴结转移者68.2%显著高于无淋巴结转移者38.0%(P<0.05);胃癌组织CD44v6的阳性表达率45.6%显著高于癌旁胃黏膜0%,有淋巴结转移者48.0%显著高于无淋巴结转移者22.7%(P<0.05);胃癌组织中αvβ6与CD44v6的表达呈正相关(P<0.05)。结论 整合素αvβ6和CD44v6在胃癌中的表达呈正相关,二者在胃癌浸润转移过程中发挥协同作用,联合检测整合素αvβ6和CD44v6的表达对胃癌的预后判断有重要的临床病理意义。
中文关键词:胃癌  αvβ6  CD44v6
 
Expression and signifigence of αvβ6 and CD44v6 in Gastric Cancer
Abstract:Objective To investigate the expression changes of αvβ6 and CD44v6 in gastric carcinoma and signifigence.Methods The expression of αvβ6 and CD44v6 were detected with EnVision immunohistochemical staining in 72 gastric carcinoma and 20 normal gastric carcinoma.Results The positive expression rate of αvβ6 in gastric carcinoma was higher than that in normal gastric carcinoma (63.8% vs 13.0%),and the positive expression rate of αvβ6 was significantly higher in the cases with metastasis than that in the cases without metastasis(68.2% vs 38.0%) (P<0.05).The positive expression rate of CD44v6 in gastric carcinoma was significantly higher than that in normal gastric carcinoma (45.6% vs 0). The positive expression of CD44 v6 was significantly higher in the cases with metastasis than that in the cases without metastasis(48.0% vs 22.7%) (P<0.05). The expression of αvβ6 and CD44v6 in gastric carcinoma are positively correlated (P<0.05).Conclusion The levels of αvβ6 and CD44v6 are up-regulated in gastric carcinoma.The combined detection of αvβ6 and CD44v6 prote in may be valuable in predicting the prognosis of gastric carcinoma.
keywords:Gastric carcinoma  αvβ6  CD44v6
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