| 三阴性乳腺癌患者化疗诱发中性粒细胞减少症对预后的影响 |
| 投稿时间：2016-04-25 修订日期：2016-05-08 点此下载全文 |
| 引用本文：周彦君,陆肖玮.三阴性乳腺癌患者化疗诱发中性粒细胞减少症对预后的影响[J].医学研究杂志,2016,45(12):125-129,96 |
| DOI：
10.11969/j.issn.1673-548X.2016.12.034 |
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| 中文摘要:目的 评估三阴性乳腺癌患者引起化疗诱导粒细胞减少症对预后的影响。方法 回顾性研究笔者医院接受环磷酰胺联合表柔比星4周期序贯多西他赛4周期（EC×4-T×4）方案化疗117例三阴性乳腺癌患者数据。按照中性粒细胞减少症程度分组，无中性粒细胞减少（中性粒细胞计数≥2.0×109/L）为1组、轻度中性粒细胞减少[（1.0~1.9）×109/L]为2组、重度中性粒细胞减少（<0.9×109/L）为3组。结果 各组临床病理特征比较，差异无统计学意义，比较1组与2组总生存时间差异有统计学意义（P=0.000），1组与3组总生存时间差异有统计学意义（P=0.022）。单因素分析中，病理T分期、N分期、Ki-67、脉管癌栓及中性粒细胞减少症是影响OS的因素（P=0.002、P=0.000、P=0.021、P=0.004、P<0.05）。在多因素分析中，轻度粒细胞减少症死亡风险比为0.581（95% CI：0.546~0.785，P=0.005），重度粒细胞减少症死亡风险比为0.623（95% CI：0.612~0.798，P=0.005）。结论 中性粒细胞减少症提示患者预后较好，可能是化疗有效性的表现。 |
| 中文关键词:乳腺癌 化疗 中性粒细胞减少症 预后 |
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| Effect of Chemotherapy-induced Neutropenia in the Prognosis in Triple Negative Breast Cancer Patients |
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| Abstract:Objective To assess the association between chemotherapy-induced neutropenia and increased survival in triple negative breast cancer patients.Methods Data from a retrospective survey for triple negative breast cancer patients in our hospital were reviewed.117 patients who had been treated with four cycles of cyclophosphamide plus epirubicin, and four cycles of doctaxel(EC×4-T×4) were studied. The patients were divided into three group according to their degree of neutropenia,group 1 was with absent neutropenia(the count of neutrophils ≥ 2.0×109/L)、group 2 was with mild neutropinia[(1.0-1.9)×109/L],group 3 was with sever neutropenia(<0.9×109/L).Results The chilinical and phathologic features in three groups had no statstical difference. In univariate analysis, the T classification, N classification,Ki-67,vascular tumor emboli and neutropenia significantly effected OS(P=0.002,P=0.000,P=0.021,P=0.004,P<0.05).In multivariate analysis, hazard ratios of death were 0.581 (95% CI:0.546-0.785; P=0.005) for patients with mild neutropenia, and 0.623 (95% CI:0.612-0.798; P=0.005) for those with severe neutropenia.Conclusion Neutropenia occurring in triple negtive breast cancer patients predicted good prognosis, It may be the biomarker of chemo-therapy efficacy. |
| keywords:Breast:cancer Chemotherapy neutropenia Prognosis |
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