| 18F-FDG PET-CT与乳腺癌新辅助化疗疗效中的关联性分析 |
| 投稿时间：2016-06-06 修订日期：2016-06-14 点此下载全文 |
| 引用本文：张立清,张喜平.18F-FDG PET-CT与乳腺癌新辅助化疗疗效中的关联性分析[J].医学研究杂志,2017,46(1):77-79 |
| DOI：
10.11969/j.issn.1673-548X.2017.01.022 |
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| 基金项目:内蒙古自治区自然科学基金资助项目（2013MS1198） |
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| 中文摘要:目的 本研究旨在探讨18F-FDG PET-CT与乳腺癌新辅助化疗疗效的关联性。方法 2014年1月~2015年12月，收集笔者医院收治的行新辅助化疗的乳腺癌患者98例。前瞻性分析18F-FDG PET-CT与乳腺癌新辅助化疗疗效的关联性。结果 与病理无效组相比，病理有效组患者SUVmax0显著增加（9.54±3.11 vs 6.12±3.21，P=0.015）；SUVmax1变化率显著增加（53%±17% vs 29%±11%，P=0.000）；SUVmax2变化率显著增加（61%±21% vs 34%±12%，P=0.000）。与未pCR组相比，pCR组患者SUVmax0显著增加（10.54±4.11 vs 5.87±2.21，P=0.000）；SUVmax1变化率显著增加（57%±17% vs 28%±10%，P=0.000）；SUVmax2变化率显著增加（64%±23% vs 33%±11%，P=0.000）。结论 18F-FDG PET-CT可作为评价乳腺癌新辅助化疗效果的一种影像学方式，值得临床进一步推广。 |
| 中文关键词:18F-FDG PET-CT 乳腺癌 新辅助化疗 疗效 |
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| Association Between 18F-FDG PET-CT and Curative Effect of Neoadjuvant Chemotherapy for Breast Cancer |
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| Abstract:Objective To investigate the association between 18F-FDG PET-CT and curative effect of neoadjuvant chemotherapy for breast cancer. Methods From Jan, 2014 to Dec, 2015, 98 patients with breast cancer admitted to our hospital were studied. The association between 18F-FDG PET-CT and curative effect of neoadjuvant chemotherapy for breast cancer was studied prospectively. Results When compared with pathological ineffective group, patients in pathological effective group got a significantly higher level of SUVmax0 (9.54±3.11 vs 6.12±3.21, P=0.015), a significant increase in SUVmax1 change rate (53%±17% vs 29%±11%, P=0.000), and a significant increase in SUVmax1 change rate (61%±21% vs 34%±12%,P=0.000). When compared with others, patients of pathology completely response got a significantly higher level of SUVmax0 (10.54±4.11 vs 5.87±2.21, P=0.000), a significant increase in SUVmax1 change rate (57%±17% vs 28%±10%, P=0.000), and a significant increase in SUVmax1 change rate (64%±23% vs 33%±11%, P=0.000). Conclusion 18F-FDG PET-CT can be used as an imaging method to evaluate the effect of neoadjuvant chemotherapy in breast cancer and is worthy worlde spreading. |
| keywords:18F-FDG PET-CT Breast cancer Neoadjuvant chemotherapy Curative effect |
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