血清血管紧张素Ⅱ水平与重症社区获得性肺炎预后的关系
投稿时间:2016-05-05  修订日期:2016-05-24  点此下载全文
引用本文:赵德军,陈琳玲,徐则兰,徐钦星,凌晓波.血清血管紧张素Ⅱ水平与重症社区获得性肺炎预后的关系[J].医学研究杂志,2017,46(1):112-115
DOI: 10.11969/j.issn.1673-548X.2017.01.031
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作者单位E-mail
赵德军 311400 杭州市富阳区第一医院呼吸内科 zhao0312699zhaoA@163.com 
陈琳玲 311400 杭州市富阳区第一医院重症监护室  
徐则兰 311400 杭州市富阳区第一医院呼吸内科  
徐钦星 311400 杭州市富阳区第一医院呼吸内科  
凌晓波 311400 杭州市富阳区第一医院呼吸内科  
基金项目:杭州市富阳区社会发展科技计划项目(2015SK004)
中文摘要:目的 探讨血清血管紧张素Ⅱ(AngⅡ)水平与重症社区获得性肺炎(SCAP)预后的关系。方法 选择30例SCAP患者纳入观察组,30例社区获得性肺炎(CAP)患者纳入对照组,比较SCAP组与CAP组患者血清CRP、D-二聚体、AngⅡ浓度,以及PSI评分;根据SCAP预后情况进行分组,比较存活组与死亡组患者血清CRP、D-二聚体、AngⅡ浓度,以及PSI评分。并分析血清CRP、D-二聚体、AngⅡ浓度与PSI评分的相关性。结果 SCAP组患者血清CRP、D-二聚体、AngⅡ浓度及PSI评分均明显高于对照组,差异有统计学意义(P<0.05);死亡组SCAP患者血清CRP、D-二聚体、AngⅡ浓度及PSI评分均明显高于存活组,差异有统计学意义(P<0.05);相关性分析显示,SCAP患者血清CRP、D-二聚体浓度与AngⅡ浓度均呈正相关(r=0.615、0.623,P<0.05);并且血清CRP、D-二聚体、AngⅡ浓度与PSI评分均呈正相关(P<0.05)。结论 血清AngⅡ浓度与CRP、D-二聚体均可反应SCAP患者的病情严重程度及预测预后,且与肺炎严重指数具有较好的相关性。
中文关键词:重症社区获得性肺炎  血管紧张素Ⅱ  预后
 
Relationship between Serum Angiotensin Ⅱ Level and Prognosis of Patients with Severe Community Acquired Pneumonia
Abstract:Objective To investigate the relationship between serum angiotensin Ⅱ (Ang Ⅱ) levels and prognosis in patients with severe community acquired pneumonia (SCAP). Methods 30 patients with SCAP were included into the observation group, and 30 cases of community get pneumonia (CAP) patients were included into the control group. The serum CRP, D-dimer, Ang Ⅱ concentration and PSI score between SCAP group and CAP group were compared. The SCAP patients were divided into death group and survival group according to the prognosis. Those indicators were compared between the two groups. And the correlation between serum CRP, D-dimer, Ang Ⅱ concentration and PSI score was analyzed. Results In the SCAP group,the serum CRP, D-dimer, Ang Ⅱ concentrations and PSI score were significantly higher than those in the control group, the difference was of statistically significant (P<0.05); and in death group of SCAP patients, the serum CRP, D-dimer, Ang Ⅱ concentrations and PSI score were significantly higher than those in the survival group, and the difference was of statistically significant (P<0.05). Correlation analysis showed that in SCAP patients, the serum CRP, D-dimer with the Ang Ⅱ concentrations were positively correlated (r=0.615,0.623,P<0.05),and the serum CRP, D-dimer, Ang Ⅱ concentrations with the PSI score were positively correlated (P<0.05). Conclusion The concentration of serum Ang Ⅱ and CRP, D-dimer can response the severity of the disease and predict the prognosis of SCAP patients, and is of good correlation with the pneumonia pneumonia severity index.
keywords:Severe community acquired pneumonia  Angiotensin Ⅱ  Prognosis
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