| 孕妇体重对妊娠糖尿病发生率、孕期肠道菌群变化及预后的影响 |
| 投稿时间：2016-08-21 修订日期：2016-11-26 点此下载全文 |
| 引用本文：王颖楠,周琴,王爱琳,杨雪,徐琴燕,石展鹰,卢丹华,赵敏.孕妇体重对妊娠糖尿病发生率、孕期肠道菌群变化及预后的影响[J].医学研究杂志,2017,46(2):70-73 |
| DOI：
10.11969/j.issn.1673-548X.2017.02.020 |
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| 基金项目:宁波市科技局基金资助项目（2012A610234） |
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| 中文摘要:目的 初步探讨孕妇体重对妊娠糖尿病发生率、孕妇肠道菌群的组成变化及预后的影响。方法 采用肠道菌群体外培养和构建细菌通用16S rRNA基因克隆文库方法，以解放军113医院妇产科常规产检孕妇作为研究对象，对产检过程中留取的排泄物标本进行肠道菌群组成的研究，同时检测体重、血糖变化；利用调查问卷方式了解孕妇营养状况、生活习惯和生活方式；最后记录分娩方式、子代出生的体格检查情况。结果 512例孕妇的检查结果显示，孕前肥胖占15.2%，而由于孕期体重增加过多导致的肥胖占17.4%；7.8%孕前和孕期肥胖组孕妇被诊断为妊娠糖尿病患者；孕前和孕期肥胖组其巨大儿发生率、剖宫产率都明显高于正常对照组（P<0.05）。与正常对照组相比，孕前和孕期肥胖组肠道菌群在门属上没有显著差别，但在种属多样性上表现不同，孕前和孕期肥胖组比正常对照组含有更多种类的厚壁菌，较少种类的拟杆菌门。结论 孕前和孕期肥胖者的妊娠期糖尿病发生率、巨大儿发生率和剖宫产率增加，同时肠道菌群多样性发生变化。因此制定孕妇健康饮食标准，在源头对孕妇肠道菌群进行调节，将会控制孕期体重增加，减少妊娠期糖尿病和并发症的发生率。 |
| 中文关键词:肥胖 妊娠期糖尿病 肠道菌群 妊娠结局 |
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| Effects of Maternal Body Weight on the Morbidity of Gestational Diabetes Mellitus,Changes of Intestinal Microflora Composition and Prognosis |
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| Abstract:Objective To investigate the effects of maternal body weight on the morbidity of gestational diabetes mellitus,changes of intestinal microflora composition and prognosisin pregnant women. Methods Intestinal microbial flora of faecal specimens from pregnant women was studied when having a heath check at the PLA 113 hospital using intestinal flora in vitro culture and 16S rRNA gene clone library construction methods. The changes of body weight and blood sugar were also detected. A questionnaire was filled out about pregnant women nutritional status, habits and lifestyles. And a medical examination of offspring was recorded and itsdelivery mode. Results The survey results showed that pre-pregnancy obesity ratio was 15.2% and obesity due to excessive weight gain during pregnancy was 17.4% of 512 pregnant women, and the ratio of gestational diabetes mellitus was 7.8% in obesity before pregnancy and during pregnancy groups. The incidence of macrosomia, cesarean section rates in obesity before pregnancy and during pregnancy groups were significantly higher than the normal weight group(P<0.05). Compared with the normal weight group, before pregnancy and during pregnancy obesity group had no significant changes in the category of intestinal flora, but obesity group contains more kinds of thick wall bacteria, fewer species of bacteroidetes. Conclusion The incidence of gestational diabetes mellitus,macrosomia and cesarean section rate were increased in obese before pregnancy and during pregnancy groups, together with changes in intestinal flora diversity. Develop healthy diet standards for pregnant women will regulate the intestinal flora at the beginning, and this will control the weight gain during pregnancy and reduce the incidence of gestational diabetes mellitus and complications. |
| keywords:Obesity Gestational diabetes mellitus Intestinal microbial flora Pregnancy outcome |
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