| 去脂体重指数对射血分数降低及射血分数保留的两类心力衰竭的诊断价值 |
| 投稿时间：2016-06-20 修订日期：2016-07-01 点此下载全文 |
| 引用本文：郑雅芬,余志敏,张丽娟,王智泉.去脂体重指数对射血分数降低及射血分数保留的两类心力衰竭的诊断价值[J].医学研究杂志,2017,46(2):96-101 |
| DOI：
10.11969/j.issn.1673-548X.2017.02.026 |
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| 中文摘要:目的 本研究通过比较不同类型心力衰竭患者中去脂体重指数（fat free mass index，FFMI）及各临床指标的不同，明确在不同类型心力衰竭患者中FFMI与各临床指标的关系，并探索FFMI对心力衰竭的诊断价值。方法 将272例心力衰竭患者依据心脏彩超左心室射血分数（left ventricular ejection fraction，LVEF）分为射血分数降低的心力衰竭（LVEF<45%）及射血分数保留的心力衰竭（LVEF≥45%），并于武汉大学中南医院体检中心选取健康对照组30例，比较两种类型心力衰竭FFMI与其他临床指标的相关性及其对心力衰竭的诊断价值。结果 FFMI在射血分数降低的心力衰竭及射血分数保留的心力衰竭中差异有统计学意义（P<0.01）；心力衰竭患者FFMI与LVEF呈正相关（r=0.371，P<0.01）；FFMI与射血分数降低的心力衰竭呈负相关（OR=0.7，95% CI：0.562~0.872）；受试者工作曲线显示当FFMI值取18.78kg/m2时，其诊断心力衰竭的效率最高，敏感度为69.1%，特异性为80.0%；而当FFMI值取17.51kg/m2时，其诊断射血分数保留的心力衰竭和射血分数降低的心力衰竭效率最高，敏感度为55.6%，特异性为78.1%。结论 心力衰竭患者FFMI越低，其心力衰竭类型为HF-rEF的可能性越大。FFMI对临床诊断心力衰竭及辨别射血分数保留的心力衰竭及射血分数降低的心力衰竭有一定的参考价值。 |
| 中文关键词:去脂体重指数 射血分数保留的心力衰竭 射血分数降低的心力衰竭 |
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| Diagnostic Value of Fat Free Mass Index in Preserved or Reduced Ejection Fraction Heart Failure |
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| Abstract:Objective To compare the differences between fat free mass index(FFMI) and other clinical indicators of heart failure,and to explorate diagnostic value of FFMI with different types of heart failure. Methods We consecutively selected 272 patients with heart failure treated in Zhongnan Hospital of Wuhan University as case group and 30 healthy subjects as control group. Heart failure patients were divided into two groups[heart failure with preserved ejection fraction(HF-pEF) group and heart failure with reduced ejection fraction(HF-rEF) group] based on their left ventricular ejection fraction(LVEF). Results FFMI was significantly lower in HF-rEF group compared to HF-pEF group. Correlation analysis showed that FFMI was significantly related to LVEF, and logistic analysis indicated that FFMI was negative related to HF-rEF. The FFMI cutoff point was 18.78kg/m2 predicted heart failure with 69.1% sensitivity and 80.0% specificity. The FFMI cutoff pointwas 17.51kg/m2 distinguished HF-pEF and HF-rEF with 55.6% sensitivity and 78.1% specificity. Conclusion FFMI is significantly different in heart failure patients and in different types of heart failure. FFMI can predict heart failure and distinguish different types of heart failure. |
| keywords:Fat free mass index Ejection fraction with reduced heart failure Ejection fraction with preserved heart failure |
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