| 孕妇血清抗AT1受体自身抗体和sEng水平对预测子痫前期的临床意义 |
| 投稿时间：2016-03-03 修订日期：2016-04-03 点此下载全文 |
| 引用本文：王英,任洁宁,安晓娜,王丽菊.孕妇血清抗AT1受体自身抗体和sEng水平对预测子痫前期的临床意义[J].医学研究杂志,2017,46(2):130-133 |
| DOI：
10.11969/j.issn.1673-548X.2017.02.034 |
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| 中文摘要:目的 本研究旨在探索和评估可溶性Endoglin（soluble Endoglin，sEng）和抗AT1受体自身抗体（angiotensin Ⅱ type1 receptor-activating antibody，AT1-AA）作为新指标预测妊娠中期孕妇子痫前期发生的可能性。方法 选择2014年8月~2015年12月诊断为子痫前期的剖宫产患者共50例，依据诊断标准分为轻度组和重度组各25例并选入30例正常孕妇作为正常组。使用全自动生化分析仪检测妊娠中期以及分娩前后AT1-AA和sEng的水平以及24h尿蛋白、平均动脉压和谷丙转氨酶（ALT）等进行比较。结果 3组孕妇的年龄、孕周以及体质量指数差异均无统计学意义（P>0.05）；而ALT、24h蛋白尿和平均动脉压在轻重度子痫患者血清中的水平均高于对照组，差异具有统计学意义（F=5.346、8.567、7.678，P=0.012、0.004、0.009）；孕妇妊娠中期、分娩前后血清中的AT1-AA和sEng水平差异有统计学意义（P<0.05），妊娠中期和分娩前，3组间两两比较差异均有统计学意义（P<0.05），而在分娩后对照组与轻度子痫组差异无统计学意义（P>0.05）；AT1-AA的敏感度为84%，特异性为92%，而sEng的敏度度和特异性分别为80%和88%，AT1-AA的曲线下面积高于sEng。结论 AT1-AA和sEng对子痫前期均具有预测价值且AT1-AA优于sEng。 |
| 中文关键词:子痫前期 可溶性Endoglin 抗AT1受体自身抗体 |
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| Clinical Significance of Angiotensin Ⅱ Type1 Receptor-activating Antibody and Soluble Endoglin in Serum Level of Pregnant Women on Predicting Preeclampsia |
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| Abstract:Objective To explore and evaluate the possibility of predicting preeclampsia of soluble Endoglin and angiotensin Ⅱ type1 receptor-activating antibody as the new indexes in pregnancy. Methods A total of 50 patients diagnosed with preeclampsia were divided into the light group(25 cases) and the severe group(25 cases) between August 2014 to December 2015 according to diagnostic criteria, and another 30 cases of normal pregnant women served as normal group. AT1-AA, sEng,urinary protein in 24 hours, mean arterial pressure and alanine aminotransferase were detected using automatic biochemistry analyzer in pregnancy medium, before and after childbirth. Results The maternal age, gestational age and body mass index of three groups showed no significant difference(P>0.05).ALT, 24h proteinuria and mean arterial pressure in patients with preeclampsia in serum levels were higher than those of the control group, the differences were statistically significant(F=5.346, 8.567, 7.678;P=0.012,0.004, 0.009).There were obvious differences in AT1-AA and sEng in pregnant metaphase, before and after delivery(P<0.05). In mid pregnancy and parturition, differences between any two groups were statistically significant, and after birth control group and no significant difference between mild preeclampsia group(P>0.05).The sensitivity of AT1-AA was 84%, the specificity was 92% and the sensitivity and specificity of sEng was 80% and 88%. The area under the curve of AT1-AA was higher than that of sEng. Conclusion AT1-AA and sEng have predictive value in preeclampsia and AT1-AA is better than sEng. |
| keywords:Spreeclampsia Soluble Endoglin Angiotensin Ⅱ type1 receptor-activating antibody |
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