| 金葡素注射液在预防结直肠癌患者辅助化疗引起的白细胞计数减少中的临床应用 |
| 投稿时间：2016-06-15 修订日期：2016-07-03 点此下载全文 |
| 引用本文：朱婷婷,黄鲁众.金葡素注射液在预防结直肠癌患者辅助化疗引起的白细胞计数减少中的临床应用[J].医学研究杂志,2017,46(2):134-137 |
| DOI：
10.11969/j.issn.1673-548X.2017.02.035 |
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| 中文摘要:目的 观察金葡素注射液预防结直肠癌术后辅助化疗引起的白细胞计数减少的疗效。方法 选取笔者所在科室2011年1月~2015年12月行Folfox6或Folfiri方案化疗的术后的结直肠癌患者120例，分为联合组（常规化疗联合金葡素注射液）和化疗组（常规化疗），观察化疗后白细胞和中性粒细胞计数减少程度以及发生的不良反应。结果 化疗组患者较联合组，更易出现白细胞和中性粒细胞计数减少（P<0.05）。联合组患者更易发生发热（P=0.016）、局部红肿（P=0.004）。结论 金葡素注射液可以有效预防化疗后白细胞计数减少，并且不良反应轻。 |
| 中文关键词:金葡素注射液 结直肠癌 骨髓抑制 化疗 |
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| Clinical Effect of Staphylococcal Enterotoxin C Injection Preventing Leucopenia Induced by Adjuvant Chemotherapy in Colorectal Cancer Patients |
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| Abstract:Objective To observe the clinical effect of staphylococcal enterotoxin C injection in preventing leucopenia induced by adjuvant chemotherapy in colorectal cancer patients. Methods A total of 120 colorectal cancer patients with the Folfox6 or Folfiri regimen adjuvant chemotherapy in our department from January 2011 to December 2015 were divided into combination group(conventional chemotherapy combined with Staphylococcal enterotoxin C injection) and chemotherapy group(conventional chemotherapy).The degree of leucopenia and neutropenia and adverse reactions after chemotherapy. Results The patients in the chemotherapy group were likely to leucopenia and neutropenia(P<0.05). The patients in the combination group were more prone to fever(P=0.016) and local redness(P=0.004). Conclusion Staphylococcal enterotoxin C injection could prevent leucopenia after chemotherapy, and the adverse reactions were mild. |
| keywords:Staphylococcal enterotoxin C injection Colorectal cancer Bone marrow depression Chemotherapy |
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