| C反应蛋白与A型主动脉夹层术后急性肾损伤的相关性 |
| 投稿时间：2016-07-28 修订日期：2016-07-28 点此下载全文 |
| 引用本文：王夕栩,王暐,龚亦群,董波,王珏,洪彪.C反应蛋白与A型主动脉夹层术后急性肾损伤的相关性[J].医学研究杂志,2017,46(3):70-73 |
| DOI：
10.11969/j.issn.1673-548X.2017.03.018 |
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| 基金项目:上海市卫生和计划生育委员会科研课题（201440430） |
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| 中文摘要:目的 探讨A型主动脉夹层患者术前C反应蛋白（C reaction protein，CRP）水平与手术后急性肾损伤（acute kidney injury，AKI）的发生的关系。方法 回顾性分析120例因急性A型主动脉夹层患者的病例资料，根据术后是否发生AKI将患者分为AKI组和非AKI组，分析患者术前、术中及术后基本信息，Logistic回归分析影响AKI发生的独立危险因素，ROC曲线判断CRP的诊断价值。结果 单因素分析结果显示AKI组患者的体重指数、C反应蛋白含量、血肌酐水平和尿素氮水平均高于非AKI组患者，差异有统计学意义（P<0.05），Logistic回归分析证实，术前CRP高表达是发生AKI的独立危险因素。CRP预测A型动脉夹层患者术后AKI的ROC曲线下面积为0.842，敏感度为86.4%，特异性为69.8%。结论 A型主动脉夹层术前CRP与手术后发生AKI显著相关，是术后发生AKI及需RRT治疗的独立危险因素。 |
| 中文关键词:主动脉夹层 急性肾损伤 C反应蛋白 肾脏替代治疗 |
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| Correlation Between Pre-operation C Reaction Protein Level and the Occurrence of Post-operation Acute Kidney Injury in A Type Aortic Dissection Patients |
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| Abstract:Objective To analyze the correlation between pre-operation C reaction protein level and the occurrence of post-operation acute kidney injury in A type aortic dissection patients. Methods One hundred and twenty patients with acute type A aortic dissection were analyzed retrospectively. Patients were divided into AKI group and non-AKI group according to whether AKI occurred after operation. The differences of the basic information before, in and after operation was analyzed. Logistic regression analysis was used to detect the independent risk factors of AKI ; ROC curve was applied to describe the diagnosis value of CRP. Results The BMI, CRP level, serum creatinine level and urea nitrogen level were much higher in patients in AKI group than in the non-AKI group (P<0.05). Logistic regression analysis confirmed that the rise of preoperative CRP was independent risk factors for AKI.The area under the ROC curve was 0.842, sensitivity 86.4%, specificity 69.8%. Conclusion Preoperative CRP is associated with the occurrence of AKI in Acute type A aortic dissection. |
| keywords:Acute aortic dissection Acute kidney injury C reactive protein Renal replacement therapy |
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