| 抗甲状腺药物治疗导致粒细胞缺乏症36例患者临床资料分析 |
| 投稿时间：2016-08-24 修订日期：2016-08-26 点此下载全文 |
| 引用本文：柴晓峰,连小兰.抗甲状腺药物治疗导致粒细胞缺乏症36例患者临床资料分析[J].医学研究杂志,2017,46(3):87-90 |
| DOI：
10.11969/j.issn.1673-548X.2017.03.022 |
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| 中文摘要:目的 分析抗甲状腺药物（ATDs）导致的粒细胞缺乏症的临床特征。方法 对北京协和医院14年间36例患者的临床资料进行回顾性分析和总结。结果 发生粒细胞缺乏患者的年龄16~62岁。88.9％的粒细胞缺乏发生在大剂量ATD治疗时。91.7%是在治疗3个月内出现。最长1例患者为持续治疗8个月时发生粒细胞缺乏。99.4%的患者继发感染。结论 ATDs诱导的粒细胞缺乏症，与年龄、性别无关。与药物种类无关，但存在剂量依赖性。 |
| 中文关键词:粒细胞缺乏 抗甲状腺药物 甲巯咪唑 丙硫氧嘧啶 粒细胞集落刺激因子 |
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| Clinical Presentations of 36 Cases of Antithyroid Drug-induced Agranulocytosis |
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| Abstract:Objective In this article, we report and discuss the clinical presentation of antithyroid drug(ATD)-induced agranulocytosis. Methods We retrospectively studied 36 cases of ATD-induced agranulocytosis over the past 14 years in PUMC hospital. Results ATD-induced agranulocytosis patient's age ranged of 16-62 years old. 88.9% of ATD-induced agranulocytosis occured with a large ATD treatment. 91.7% patients occured in the first three month of drug therapy. A case occured agranulocytosis when 8 months duration.94.4% patients occurs secondary infections. Conclusion This study showed that ATD-induced agranulocytosis considered to be dose dependent, not irrelevant to sex,age and the drug. |
| keywords:Agranulocytosis Antithyroid drugs Methimazole Propythiouracil Granulocyte clony-stimulating factor |
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