| 甲状腺功能减退孕妇孕晚期脐血流S/D比值的变化 |
| 投稿时间：2016-06-20 修订日期：2016-07-10 点此下载全文 |
| 引用本文：孙莹,舒立波,徐红波.甲状腺功能减退孕妇孕晚期脐血流S/D比值的变化[J].医学研究杂志,2017,46(4):90-92 |
| DOI：
10.11969/j.issn.1673-548X.2017.04.023 |
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| 基金项目:浙江省医药卫生科技计划项目（2013KYB240） |
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| 中文摘要:目的 探讨妊娠合并甲状腺功能减退（以下简称甲减组）和妊娠合并亚临床甲状腺功能减退孕妇孕晚期脐动脉血流S/D比值（S/D值）的变化及其与甲状腺功能的相关性。方法 选择2014年1月~2015年12月住院的孕晚期孕妇，剔除可能影响脐血流的合并症后，将孕妇分为甲减组、亚甲减组和正常对照组，比较3组孕妇S/D比值的不同，分析S/D比值与血清TSH、FT4、FT3的相关性。结果 甲减组S/D值（2.46±0.31）与亚甲减组S/D值（2.48±0.27）均高于对照组（2.32±0.17），P值均为0.000。亚甲减组与甲减组比较，差异无统计学意义（P=0.907）。3组间不同脐动脉血流S/D值区间病例数构成比，差异有统计学意义（P=0.000）。甲减组孕妇S/D比值与血清TSH呈正相关（r=0.186，P=0.037），与血清FT4、FT3无相关性（P > 0.05），亚甲减组孕妇S/D比值与血清TSH呈正相关（r=0.146，P=0.015），与血清FT4、FT3无相关性（P > 0.05），对照组S/D比值与血清TSH、FT4、FT3均无相关性（P > 0.05）。结论 甲状腺功能减退状态有可能影响孕晚期脐动脉血流。 |
| 中文关键词:妊娠晚期 甲状腺功能减退症 亚临床甲状腺功能减退 甲状腺激素 脐动脉血流S/D比值 |
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| Change of S/D Value in the Third trimester Pregnancy with Hypothyroidism |
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| Abstract:Objective To observe the change of umbilical artery S/D value in the third trimester pregnant women with overt hypothyroidism(OH) or subclinical hypothyroidism(SCH). Methods We collect the data of 37-42 weeks pregnancy from January 2014 to December 2015.We devided them into OH group,SCH group and contral group.We compared the umbilical artery S/D value in these three groups and analyzed the relativity between S/D value and thyroid hormone. Results The S/D value was 2.46±0.31 in OH group,2.48±0.27 in SCH group and 2.32±0.17 in control group.The differences were statistically significant between OH group and contral group (P=0.000),SCH group and contral group (P=0.000).There was no statistically significant between OH group and SCH group(P=0.907).The proportion of cases number during different S/D value range in these three groups had difference(P=0.000).The S/D value was positively correlated to TSH in OH group(r=0.186,P=0.037) and SCH group(r=0.146,P=0.015).There was no correlation between FT3 and S/D value(P > 0.05) or FT4 and S/D value(P > 0.05) in both OH and SCH group.There was no correlation between thyroid hormone and S/D value in the contral group either. Conclusion Both OH and SCH can effect umbilical artery S/D value in the third trimester pregnancy. |
| keywords:Third trimester pregnancy Overt hypothyroidism Subclinical hypothyroidism Thyroid hormone umbilical artery systolic- to-diastolic ratio |
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