| 甲硝唑与克拉霉素治疗重度慢性牙周炎的对比研究 |
| 投稿时间：2016-08-15 修订日期：2016-09-14 点此下载全文 |
| 引用本文：杜建红,卢灿,赵春萍,周晶晶,李卫国.甲硝唑与克拉霉素治疗重度慢性牙周炎的对比研究[J].医学研究杂志,2017,46(4):96-99 |
| DOI：
10.11969/j.issn.1673-548X.2017.04.025 |
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| 基金项目:新疆维吾尔自治区地区基金资助项目（2015211C055） |
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| 中文摘要:目的 对比甲硝唑与克拉霉素治疗重度慢性牙周炎的临床治疗效果，为重度慢性牙周炎的药物辅助治疗提供参考依据。方法 观察组为2015年6月~2016年3月收治的112例重度慢性牙周炎患者，经口腔常规基础治疗后给予克拉霉素口服治疗，对照组为既往2015年1~6月收治的115例重度慢性牙周炎患者，经口腔常规基础治疗后甲硝唑口服治疗。比较两组治疗前与治疗后3个月龈沟出血指数（sulcus bleeding index， SBI）、 牙周探诊深度（probing depth，PD）、牙周附着水平（attachment level，AL），检测并比较两组治疗前及治疗7天后龈沟液中白细胞介素-1（interleukin-1，IL-1）、肿瘤坏死因子的变化α（tumor necrosis fator-α，TNF-α）的改变。结果 比较两组间SBI、PD、AL，差异无统计学意义（P > 0.05）。治疗3个月后，其值均较治疗前降低，且观察组PD、AL较对照组低，差异有统计学意义（P < 0.05），但SBI值差异无统计学意义（P > 0.05）。比较两组间炎性因子IL-1、TNF-α改变，在治疗前无明显改变，差异无统计学意义（P > 0.05）。治疗7天后，其值均较治疗前下降，且观察组IL-1、TNF-α较对照组低，差异有统计学意义（P < 0.05）。结论 克拉霉素治疗重度慢性牙周炎的效果及优于甲硝唑，值得临床推广。 |
| 中文关键词:牙周炎 甲硝唑 克拉霉素 |
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| Research of Comparing of Effect of Metronidazole with Clarithromycin in Severe Chronic periodontitis. |
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| Abstract:Objective To compare the clinical effect of metronidazole and clarithromycin in severe chronic periodontitis,and provide the evidence and reference for treatment. Methods 112 severe chronic periodontitises were treated by clarithromycin after they had accepted the dental basic treatment formerly and this group were regarded as the observation group.Other group were consisted of 115 severe chronic periodontitises who were treated by metronidazole after they had accepted the dental basic treatment formerly and we regarded these patients as the control group.We compared the above two group data such as sulcus bleeding index(SBI), probing depth(PD) and attachment level(AL) at before treatment and after treatment 3 months. We compared the two group data,interleukin-1(IL-1) and tumor necrosis factor -α (TNF -α)at before treatment and after 7 days. Results Both groups' date such as SBI, PD and AL had no significant difference statistically(P > 0.05) before treatment.When after 3 months treatment, both two groups' date such as SBI, PD and AL were lower than before treatment(P < 0.05),and the observation groups' date such as PD and AL were lower than control group(P < 0.05).Both groups' date such as interleukin-1and tumor necrosis factor -α were no significant difference statistically(P > 0.05) before treatment. When after 7 days treatment, the two groups' date such as interleukin-1and tumor necrosis factor-α were lower than before treatment(P < 0.05),and the observation groups' date such as interleukin-1and tumor necrosis factor-α were lower than conctrol group(P < 0.05). Conclusion Clarithromycin could be used in the treatment of severe chronic periodontitis with significant clinical effects. |
| keywords:Periodontitis Metronidazole Clarithromycin |
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