| Abstract:Objective To explore the relationship between metabolic syndrome (MS) and obesity in obese children, and to explore the risk factors of MS. Methods The study included 56 obese children (26 boys and 30 girls) and 50 non-obese controls (25 boys and 25 girls). Anthropometry, fasting glucose, insulin concentrations, total cholesterol, high density lipoprotein (HDL), low density lipoprotein (LDL), triglycerides, systolic and diastolic blood pressure(BP) were measured in both of groups. Insulin resistance was determined by HOMA-IR. Finally subcutaneous and visceral fat thicknesses were measured by ultrasonographically. Results Obese children with metabolic syndrome had a high level of BMI, waist circumference, insulin levels, HOMA-IR, TG, blood pressure and visceral fat thickness than obese children without metabolic syndrome, but HDL-C was over than control group. The proportion of obese children with insulin ≥15μU/ml, HOMA-IR≥3.4 and TG≥150mg/dl was significantly higher, while the proportion of HDL-C<40mg/dl was significantly lower than the control group. In logistic regression analysis showed that HOMA-IR≥3.4, TG≥150mg/dl and HDL-C<40mg/dl was strongly associated with the occurrence of MS and the risk was increased with the HOMA-IR score. The ORs of MS recurrence in obese children with HOMA-IR score between 3.4-4.9 was 3.8 compared with the reference group. That of HOMA-IR≥5 was 5.7, that of TG≥150mg/dl was 4.2, that of HDL-C<40mg/dl was 3.4 (P < 0.05). Conclusion Children with HOMA-IR score between 3.4-4.9, HOMA-IR≥5, TG≥150mg/dl or HDL-C<40mg/dL have an significantly increased risk for metabolic syndrome. So for these obese children, we should advance screening of high-risk patients and intervene as early as possible to prevent the occurrence of metabolic syndrome and its complications. |
