| 甲状腺功能减退患者认知功能与抑郁的相关性研究 |
| 投稿时间：2016-08-03 修订日期：2016-09-03 点此下载全文 |
| 引用本文：张妍,王晓光,张兰,焦凯.甲状腺功能减退患者认知功能与抑郁的相关性研究[J].医学研究杂志,2017,46(4):132-135 |
| DOI：
10.11969/j.issn.1673-548X.2017.04.034 |
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| 中文摘要:目的 了解甲状腺功能减退患者的认知功能与抑郁状况，并探索两者之间的相关性。方法 收集甲状腺功能减退患者45例和对照组25例，运用蒙特利尔认知功能评估量表（MOCA）及汉密尔顿抑郁量表（HAMD）评定患者的认知功能及抑郁状况，分析MOCA评分与HAMD评分之间的相关性。结果 甲减组认知功能障碍及抑郁的发生率均高于对照组，差异有统计学意义（P < 0.05）；甲减组MoCA总分、视空间与执行功能、记忆与延迟记忆分项得分低于对照组，差异有统计学意义（P < 0.05）；甲减患者HAMD得分与MoCA总分、视空间与执行功能、记忆与延迟记忆分项得分呈显著负相关（P < 0.05）。结论 甲减患者常存在明显的认知功能障碍及抑郁障碍，且抑郁与认知功能密切相关。 |
| 中文关键词:甲状腺功能减退症 认知功能 抑郁 |
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| Correlation Between Cognitive Function and Depression in Patients with Hypothyroidism |
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| Abstract:Objective To understand the cognitive function and depression status in patients with hypothyroidism, and to explore the correlation between them. Methods The cognitive function and depression status of 45 patients with hypothyroidism and 25 normal groups were evaluated with Montreal cognitive assessment(MOCA)and Hamilton depression scale(HAMD).The correlation between MoCA score and HAMD score were analyzed. Results The incidence of depression and cognitive dysfunction in the case group was significantly higher than the control group(P < 0.05); The MOCA score, visual space and executive function score, memory and delayed memory score in case group was significantly lower than the control group and significantly negatively related to the HAMD score(P < 0.05). Conclusion Hypothyroidism patients often have cognitive dysfunction and depression obviously, and depression is closely related to cognitive function. |
| keywords:Hhypothyroidism Cognitive function Depression |
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