| 平均血小板体积变化在急性胰腺炎中的临床意义及治疗效果评估价值 |
| 投稿时间：2016-09-09 修订日期：2016-10-08 点此下载全文 |
| 引用本文：张梦然,张玫,孙书春.平均血小板体积变化在急性胰腺炎中的临床意义及治疗效果评估价值[J].医学研究杂志,2017,46(5):136-140 |
| DOI：
10.11969/j.issn.1673-548X.2017.05.034 |
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| 中文摘要:目的 探讨平均血小板体积等参数在急性胰腺炎病程中变化的临床意义及其对治疗效果评估的价值。方法 回顾性分析53例轻症急性胰腺炎（MAP）患者、25例重症急性胰腺炎（SAP）患者和40例健康者（对照组）的临床资料，检测平均血小板体积（MPV）、血小板计数（PLT）、血小板分布宽度（PDW）、白细胞计数（WBC）、C反应蛋白（CRP）及血清钙离子浓度（Ca2+）等指标。比较并分析上述指标在急性胰腺炎病程中及治疗前后的变化。结果 与对照组比较，急性胰腺炎患者入院时MPV显著升高，差异具有统计学意义（P<0.05）；与MAP组比较，SAP组入院时MPV明显升高，差异具有统计学意义（P<0.05）；SAP组中，MPV在入院后第3天较入院时进一步升高，至入院第5天、第7天逐渐下降；SAP组中，MPV在病程中各时间点与MAP组比较均显著升高，差异有统计学意义（P<0.05）；与治疗前比较，急性胰腺炎患者治疗后MPV显著降低，差异有统计学意义（P<0.05）。结论 急性胰腺炎患者平均血小板体积与病情严重程度及治疗效果相关。 |
| 中文关键词:急性胰腺炎 平均血小板体积 血小板参数 |
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| Clinical Significance of Mean Platelet Volume Variation in Acute Pancreatitis and Its Value in Evaluation Therapeutic Effect |
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| Abstract:Objective To investigate the possible role of mean platelet volume and its value as a therapeutic effect in acute pancreatitis (AP). Methods Data of 78 cases of AP and 40 cases of negative control were retrospectively analyzed. Mean platelet volume (MPV),platelet counts (PLT), platelet distribution width (PDW), leucocyte count (WBC),C reactive protein (CRP) and serum level of calcium (Ca2+) were measured and analyzed on the admission day, 3th, 5th and 7th day. Results The MPV values were elevated obviously in AP group on the admission day. Moreover, the MPV values of SAP group were significantly higher than those of MAP group on the admission day. The MPV values were decreased at 5 days and 7 days after admission followed by a increasing at 3 days in SAP group. Furthermore, the MPV value of SAP group at every time point was significantly higher than those of MAP group. The MPV values of AP patients showed a significant reduce after treatment. Conclusion MPV was associated with the severity and the treatment effect of acute pancreatitis. |
| keywords:Acute pancreatitis Mean platelet volume Platelet parameters |
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