| 脐血间充质干细胞治疗慢性乙型肝炎加急性肝衰竭的疗效分析 |
| 投稿时间：2016-10-13 修订日期：2016-10-30 点此下载全文 |
| 引用本文：杨丽,马英杰,刘桂举,韩莉.脐血间充质干细胞治疗慢性乙型肝炎加急性肝衰竭的疗效分析[J].医学研究杂志,2017,46(6):151-153 |
| DOI：
10.11969/j.issn.1673-548X.2017.06.039 |
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| 中文摘要:目的 探讨脐血间充质干细胞（umbilical cord-derived mesenchymal stem cells，UCMSCs）在治疗慢性乙型肝炎加急性肝衰竭的疗效。方法 收集笔者医院2013~2015年收治的慢性乙型肝炎加急性肝衰竭患者84例，根据治疗方案分为对照组44例，观察组40例。对照组采用标准治疗以及人工肝等综合治疗，观察组在综合治疗的基础上加用脐血间充质干细胞输注。观察两组患者治疗过程中的临床症状改善情况，并在治疗前后分别检测两组患者血清白蛋白（ALB）、总胆红素（TBil）、和凝血酶原活动值（PTA）。结果 观察组患者有效率明显高于对照组，住院时间短于对照组，死亡患者的生存时间长于对照组。结论 脐血间充质干细胞可有效的改善慢性乙型肝炎加急性肝衰竭症状，提高生存率。 |
| 中文关键词:间充质干细胞 肝衰竭 治疗 |
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| Study of Human Umbilical Cord Derived Mesenchymal Stem Cells in Treatment of HBV-related Acute-on-chronic Liver Failure |
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| Abstract:Objective To investigate the effect of injection of human umbilical cord -derived mesenchymal stem cells in treatment of HBV-related acute-on-chronic liver failure. Methods Eighty-four patients with HBV-related acute-on-chronic liver failure in our hospital from December 2013 to December 2015 were included. They were randomly assigned to two groups, with 44 patients in control group and 40 patients in observation group. The control group was given the standard therapy of severe hepatitis and artificial liver support system. The observation group was given the standard therapy for HBV-related acute-on-chronic liver failure and artificial liver support system combined with intravenous infusion of human umbilical cord-derived mesenchymal stem cells. Changes of clinical efficacy were observed in each group during the treatment period. The levels of ALB,TBIL,PTA of each group were detected before and after comprehensive therapy. Results The effective rate in observation group was higher than that in control group.The average duration of hospital stay of observation group was significantly shorter than that of the control group,while the mean survival time of observation group was longer than that of the control group. Conclusion Symptoms in patients suffered from HBV-related acute-on-chronic liver failure with intravenous infusion of human umbilical cord blood combined can get quickly alleviated, and the survival rate is greatly improved. |
| keywords:Mesenchymal stem cells Liver failure Treatment |
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