| ABO血型与脓毒血症并发急性肾损伤相关性研究 |
| 投稿时间：2016-11-11 修订日期：2016-11-29 点此下载全文 |
| 引用本文：徐亮,陈星华,丁国华.ABO血型与脓毒血症并发急性肾损伤相关性研究[J].医学研究杂志,2017,46(7):41-43 |
| DOI：
10.11969/j.issn.1673-548X.2017.07.010 |
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| 基金项目:国家自然科学基金资助项目（面上项目）（81500516） |
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| 中文摘要:目的 探讨ABO血型与脓毒血症并发急性肾损伤的相关性，为其提供防治依据。方法 选取武汉大学人民医院重症医学科2015年1~12月收治的130例脓毒症患者，将其分为合并AKI组（观察组64例）与非合并AKI组（对照组66例），分析比较两组一般资料以及实验室指标，采用多因素Logistic回归分析筛选出脓毒血症患者发生急性肾损伤的相关危险因素。结果 研究共选入脓毒血症急性肾损伤64例，对照组脓毒血症非急性肾损伤66例，急性肾损伤组年龄高于对照组（65.7±13.1岁 vs 58.5±15.4岁，P=0.005），男性比例高于对照组（76.6% vs 56.1%，P=0.014），降钙素原定量高于对照组（28.1±21.0μg/L vs 21.1±13.6μg/L，P=0.026）。血培养阳性率高于对照组（30.2% vs 15.3%，P=0.006），两组ABO血型分布差异无统计学意义（P=0.825）。两组在白细胞计数、C反应蛋白水平比较，C反应蛋白、部分活化凝血酶时间观察组均高于对照组，白蛋白水平低于对照组，差异无统计学意义。影响脓毒血症合并AKI发病的相关危险因素：Logistic回归模型多因素分析表明：年龄（P=0.021，OR=0.965），性别（P=0.003，OR=5.321），降钙素原定量（P=0.047，OR=0.975），血培养阳性（P=0.002，OR=1.009），血型A与血型O比较（P=0.037，OR=5.409）均与脓毒血症合并急性肾损伤相关。结论 提示A型血与脓毒血症合并急性肾损伤存在独立相关性，A型血可能增加脓毒血症合并急性肾损伤的风险。 |
| 中文关键词:ABO血型 脓毒血症 急性肾损伤 |
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| ABO Blood Type Correlates with Sepsis Complicated with Acute Kidney Injury |
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| Abstract:Objective To investigate the ABO blood type and sepsis complicated with acute kidney injury, to provide the basis for prevention and treatment. Methods A total of 130 patients with sepsis from renmin hospital of Wuhan University intensive care unit from january 2015 to december 2015 were enrolled in this study, divided into complicated AKI group (64 patients in the observation group) and non-complicated AKI group (66 patients in the control group), analyzed two groups of general data, laboratory indicators,multivariate logistic regression analysis was used to screen out the risk factors for AKI in patients with sepsis. Results A total of 64 patients with AKI were collected from the observation group and 66 patients with non-AKI in the control group, the age of the observation group was higher than that of the control group (65.7±13.1 years old vs 58.5±15.4 years old, P=0.005), male proportion was higher than control group (76.6% vs 56.1%, P=0.014), drop calcium pigment original quantitative was higher than control group (28.1±21.0μg/L vs 21.1±13.6μg/L, P=0.026), positive blood culture rate was higher than in the control group (30.2% vs 15.3%, P=0.006).There was no significant difference in ABO blood group distribution between the two groups (P=0.825). The levels of white blood cell count, C-reactive protein and partially activated thrombin were higher in the observation group than in the control group,the platelet count and albumin level were lower than those in the control group, the difference was not statistically significant. The risk factors associated with the incidence of sepsis with AKI were analyzed by multivariate analysis of the logistic regression model:age(P=0.021, OR=0.965), gender(P=0.003, OR=5.321), calcitonin-original(P=0.047, OR=0.975), positive blood culture (P=0.002, OR=1.009), comparison of type A blood and type O blood (P=0.037,OR=5.409) were associated with sepsis complicated with AKI. Conlusion Type A blood and sepsis with AKI associated with the existence of independent correlation, type A blood may increase the risk of sepsis with AKI. |
| keywords:ABO blood type Sepsis AKI |
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