| 中药制剂对代谢综合征干预效应的Meta分析 |
| 投稿时间：2016-12-25 修订日期：2017-01-12 点此下载全文 |
| 引用本文：刘艳飞,李博,刘玥,高蕊.中药制剂对代谢综合征干预效应的Meta分析[J].医学研究杂志,2017,46(8):49-55 |
| DOI：
10.11969/j.issn.1673-548X.2017.08.013 |
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| 基金项目:国家中医药管理局中医药科学技术研究专项基金资助项目（2016ZX10） |
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| 中文摘要:目的 系统评价中药制剂治疗代谢综合征的有效性和安全性。方法 检索PubMed、VIP、WanFang date、CBM、CNKI等数据库，纳入中药制剂治疗代谢综合征的随机对照临床试验。按照纳排标准对文献进行筛选、资料提取，并根据《Cochrane干预措施系统评价手册》进行文献质量评价，采用RevMate5.3软件对空腹血糖、甘油三酯、胆固醇、收缩压、舒张压进行Meta分析，并进行安全性评价。结果 最终纳入12个RCT，共计纳入1129例患者。Meta分析结果显示，与西药标准化治疗或常规治疗相比，中药制剂在治疗代谢综合征过程中，可以改善甘油三酯水平（MD=-0.51，95% CI：-0.73~-0.28）、胆固醇（MD=-0.84，95% CI：-1.47~-0.21）、低密度脂蛋白水平（MD=-0.21，95% CI：-0.41~-0.01）、收缩压水平（MD=-4.12，95% CI：-7.29~-0.95），表明联合中药制剂具有调节脂质代谢和降低收缩压的作用；对空腹血糖（MD=-0.045，95% CI：-0.95~0.05）及舒张压（MD=-2.58，95% CI：-5.86~0.69）的作用差异无统计学意义。12个研究中有4个研究报告了不良反应，1项研究报道了治疗组有5例在治疗开始后出现大便次数增多，减量或继续治疗3天后症状消失。1项研究报道了治疗组出现胃脘不适3例，改饭后服药或中药加减治疗后缓解。其余的文献未对不良反应做系统报告。结论 与西药标准化治疗相比，中药制剂在治疗代谢综合征方面有一定的干预效应，具有降低血压及调节脂质代谢的作用，安全性尚可，不良反应少见。但纳入的研究方法学质量偏低，上述结论需要后续开展更多高质量的研究予以验证。 |
| 中文关键词:代谢综合征 中药制剂 Meta分析 |
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| Effect of Chinese Herbal preparations on Metabolic Syndrome:a Meta-analysis |
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| Abstract:Objective To systematically review the efficacy and safety of Chinese Herbal preparations in improving Metabolic Syndrome (MS). Methods We searched in PubMed, MEDLINE, EMBASE, CNKI, VIP, Wanfang data, China Biology Medicine (CBM) for reports published before Aug 2016. We searched randomized controlled trials (RCT) for Chinese herbal preparations treating metabolic syndrome. The Cochrane Collaboration RevMan 5.3 software was used for data analysis of effects of Chinese herbal preparations treating MS including fasting plasma glucose (FPG), triglyceride (TG), cholesterol (TC), diastolic blood pressure (DBP) and systolic blood pressure (SBP). Safety evaluation of Chinese herbal preparations was studied as well. Results A total of 12 RCTs were enrolled in the study, involving 1129 cases of patients. Meta-analysis showed that compared with non-TCM treatment, standard treatment of Western medicine or conventional treatment, treatment combined with Chinese herbal preparations could improve Triglyceride (TG) (MD=-0.51,95%CI:-0.73--0.28), Cholesterol (TC) (MD=0.84, 95%CI:-1.47--0.21), LDL-C (MD=-0.21,95%CI:-0.41--0.01), SBP (MD=-4.12,95%CI:-7.29--0.95), which meant that Chinese herbal preparations has a role in decreasing SBP and improve serum lipid metabolism. The effects of FPG and DBP were not statistically significant. 4 of the 12RCTs reported adverse events, and a total of 2 cases of adverse reactions occurred in the experimental group. Symptoms of adverse reactions including stomachache and loose stool. Conclusion Compared with non-TCM treatment, standard treatment of Western medicine or conventional treatment, treatment combined with Chinese herbal preparations could improve TG, TC and reduce SBP in patients with metabolic syndrome. Rare adverse reactions occurred and safety evaluation was acceptable. However, due to low methodological quality of the enrolled studies, the results of this work need further clinical researches. |
| keywords:Metabolic syndrome Chinese herbal preparations Meta-analysis |
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