| 视神经脊髓炎谱系疾病患者的临床特征分析 |
| 投稿时间：2016-10-28 修订日期：2016-12-20 点此下载全文 |
| 引用本文：王超慧,夏德雨.视神经脊髓炎谱系疾病患者的临床特征分析[J].医学研究杂志,2017,46(8):135-138 |
| DOI：
10.11969/j.issn.1673-548X.2017.08.033 |
| 摘要点击次数: 1342 |
| 全文下载次数: 651 |
|
| 基金项目:中国人民解放军海军总医院创新培育基金资助项目（CXPY201623） |
|
| 中文摘要:目的 分析视神经脊髓炎（NMO）与视神经脊髓炎谱系疾病（NMOSD）患者的临床特点。方法 采用回顾性研究方法，2013年2月~2016年9月选择在海军总医院进行诊治的NMO患者72例（NMO组）和NMOSD患者72例（NMOSD组）作为研究对象，记录两组患者的一般人口学资料、眼部症状、脊髓与头颅MRI影响、NMO-IgG检测结果。结果 两组性别、年龄比较差异无统计学意义（P>0.05）。NMOSD组的临床首发表现、发病频率与病程与NMO组比较差异有统计学意义（P<0.05）。NMOSD组中表现为视力下降8例，视野缺损4例，视物变色3例，复视5例；而NMO组中表现为视力下降32例，视野缺损14例，视物变色12例，复视21例，两两比较差异均有统计学意义（P<0.05）。在NMOSD组中，脊髓MRI表现为正常8例，异常64例，头颅MRI中有32例出现脑部病灶。NMO组脊髓MRI都表现为异常，头颅MRI中有28例出现脑部病灶。NMO组的血清阳性率为41.7%，NMOSD组血清阳性率为59.7%。AQP4-Ab抗体诊断NMO的敏感度为44.4%，特异性为75.0%；AQP4-Ab诊断NMOSD的敏感度为61.1%，诊断NMOSD的特异性为75.0%。结论 NMOSD好发于女性，首发症状表现复杂，以脊髓灰质受累为主，能诱发促进出现脑部病灶，NMO-IgG抗体可作为NMOSD的支持诊断依据。 |
| 中文关键词:视神经脊髓炎谱系 视神经脊髓炎 临床特征 AQP4-Ab抗体 眼部症状 |
| |
| Analysis of Clinical Features of Patients with Neuromyelytis Opica and Spectrum of Neuromyelytis Opica |
|
|
| Abstract:Objective To discuss the clinical characteristics of patients withclinical features of patients with neuromyelytis opica and spectrum of neuromyelytis opica(NMOSD) and neuromyelitis optica (NMO). Methods With a retrospective study, From February 2013 to September 2016, a total of 72 NMO patients in Navy General Hospital for diagnosis and treatment were selected as the NMO the NMO group and the other 72 patients of NMOSD patients were selected as the NMOSD group. The results of two groups of patients with general demographic data, ocular symptoms, spinal cord and brain MRI, influence NMO-IgG were recorded. Results There were no significant differences in gender and age compared between the two groups (P>0.05). The clinical characteristics, frequency and duration in the NMOSD group compared to the NMO group were significantly different (P<0.05). In the NMOSD group, there were 8 patients who were decreased vision, 4 patients were visual field defect, 3 patients were discoloration, 5 patients were diplopia. While in the NMO group, 32 patients were decreased visual acuity, 14 patients were visual field defect, 12 patients were color vision, 21 patients were diplopia.There were statistically significant difference between the two groups (P<0.05). In the NMOSD group, there were 8 patients were MRI of the spinal cord were normal, 64 patients were abnormal and 32 patients of brain lesions in the head MRI. In the NMO group, MRI of the spinal cord were all abnormal, and there were 28 patients were brain lesions in the head MRI. The serum positive rate of NMO group was 41.7%, and the serum positive rate of NMOSD group was 59.7%. The sensitivity of AQP4-Ab antibody to NMO was 44.4%, the specificity was 75%, the sensitivity of AQP4-Ab was 61.1%, and the specificity of NMOSD was 75%. Conclusion The NMOSD is more with female patients, the first symptom is more with the spinal cord that the gray matter involvement in the spinal cord, and the performance of complex, NMO-IgG antibody can be used as a support for NMOSD diagnosis. |
| keywords:Neuromyelytis opica and spectrum of neuromyelytis opica Neuromyelitis optica Clinical features AQP4-Ab antibody Ocular symptoms |
| 查看全文 查看/发表评论 下载PDF阅读器 |
|
|
|
